AI Article Synopsis
- Porokeratosis is a skin disorder characterized by a specific layer of keratinization called the cornoid lamella, with various clinical and histological variants.
- A case of porokeratosis with significant melanocytic hyperplasia was analyzed to rule out melanoma, revealing that 25.8% of studied cases showed this benign condition.
- The authors introduce the term "pigmented porokeratosis" for this variant and emphasize the importance of correctly identifying it to prevent misdiagnosis as melanoma in situ.
Article Abstract
Porokeratosis is a clonal disorder of keratinization characterized by the presence of the cornoid lamella. A number of variants of porokeratosis have been described, based on the clinical features and histologic features of the lesions. The authors present a case of porokeratosis with prominent melanocytic hyperplasia, which was biopsied to clinically exclude melanoma. The authors retrospectively studied cases of porokeratosis to look for the presence of melanocytic hyperplasia. Melanocytic hyperplasia was identified in 8 of 31 cases (25.8%). All of the cases except the index case were clinically nonpigmented but arose in solar damaged skin. This case represents a distinct variant of porokeratosis, and the authors propose the designation pigmented porokeratosis. Melanocytic hyperplasia is a benign condition, and it is important that this is not histologically confused with melanoma in situ, particularly in a context of clinically pigmented lesion. Increased recognition of pigmented porokeratosis is essential to avoid an erroneous diagnosis of melanoma in situ.
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| http://dx.doi.org/10.1097/DAD.0000000000000468 | DOI Listing |
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