Eccrine porocarcinoma (EPC) is a potentially lethal neoplasm of the skin that arises from the intraepidermal portion of the eccrine sweat glands. It was previously known as eccrine adenocarcinoma or malignant eccrine poroma. It commonly occurs between 60 to 80 years of age, usually arising from hands and feet. However, few case reports on involvement of rare sites such as scalp, face and eyelids are present in literature. We herein report an unusual case of porocarcinoma arising on the right parieto occipital region of scalp in a 29-year-old young female patient. To the best of our knowledge, there have been fewer than 20 cases of porocarcinoma arising on scalp with fewer than 10 cases seen in younger age group reported previously in the literature.
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http://dx.doi.org/10.7860/JCDR/2016/16083.7149 | DOI Listing |
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Friendship Hospital, Beijing100029, China.
Clin Case Rep
December 2024
Department of Dermatology Razi Hospital, Tehran University of Medical Sciences (TUMS) Tehran Iran.
Representative clinical images in this study can increase awareness regarding the clinical similarity between this benign adnexal tumor and malignant melanoma and highlight the importance of pathological examination.
View Article and Find Full Text PDFAn Bras Dermatol
December 2024
Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Background: Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm, commonly arising from its benign counterpart, eccrine poroma (EP), but potential unrevealed clinicopathological differences between them are not well understood.
Objectives: This study aimed to identify clinicopathological features of EP and EPC and describe the factors that may be associated with the malignant transformation of EP by comparing the two groups.
Methods: A total of 37 cases of EP and 22 cases of EPC diagnosed between January 2017 and June 2023 were retrospectively reviewed, and the clinical and histopathological characteristics were compared using statistical methods.
Diagnostics (Basel)
October 2024
Dermatology Department, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, 1000 Brussels, Belgium.
Int J Dermatol
October 2024
Division of Subspecialty Medicine, Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
A 70-year-old African American female with a history of stage IV mycosis fungoides in remission presented with a gradually enlarging, red, ulcerated nodule on her right dorsal hand. The lesion was biopsied, and it showed intraepidermal proliferation with cytologic atypia and increased vasculature in the papillary dermis. Immunohistochemical staining indicated a yes-associated protein 1 (YAP1) rearrangement, confirmed by RNA sequencing, revealing a YAP1::MAML2 (mastermind-like transcriptional coactivator 2) fusion.
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