AI Article Synopsis
- Streptomyces silvensis produces nonribosomal peptides that inhibit human oxytocin and vasopressin receptors.
- The genome sequence of S. silvensis ATCC 53525 was analyzed and found to contain multiple biosynthetic gene clusters.
- This organism shows potential as a valuable resource for developing new drugs through genome-guided discovery.
Article Abstract
Streptomyces silvensis produces nonribosomal peptides that act as antagonists of the human oxytocin and vasopressin receptors. Here, we present the genome sequence of S. silvensis ATCC 53525 and demonstrate that this organism possesses a number of additional biosynthetic gene clusters and might be a promising source for genome-guided drug discovery efforts.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759055 | PMC |
| http://dx.doi.org/10.1128/genomeA.00001-16 | DOI Listing |
Publication Analysis
Top Keywords
genome sequence
8
streptomyces silvensis
8
silvensis atcc
8
atcc 53525
8
draft genome
4
sequence streptomyces
4
53525 producer
4
producer novel
4
novel hormone
4
hormone antagonists
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!