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Eco-logistical comparison of non-radioactive seeds and the wire-guided localization for intraoperative detection of breast lesions.
Eur J Surg Oncol
January 2025
Department of Obstetrics and Gynecology, University Hospital Ulm, Prittwitzstr. 43, 89075, Ulm, Germany.
Background: The current standard for the preoperative marking of non-palpable breast lesions is wire guided localization (WGL) which is associated with logistical efforts and patient discomfort. Non-radioactive seeds (NRS) recently challenged the use of WGL; but do they provide a better alternative from a logistical and environmental perspective?
Methods: WGL standard was compared with NRS available in Germany: Magseed®, Pintuition®, SAVI SCOUT ® and LOCalizer™ on a logistical and carbon-footprinting basis. In the logistical analysis the number of patient contacts with the healthcare system for lesion localization/removal and the number of breast punctures were evaluated in two different clinical scenarios (primary surgery and secondary surgery after neoadjuvant treatment).
Inter-fractional error and intra-fractional motion of prostate and dosimetry comparisons of patient position registrations with versus without fiducial markers during treatment with carbon-ion radiotherapy.
Radiol Phys Technol
June 2024
National Institutes for Quantum Science and Technology, QST Hospital, Chiba, Japan.
Article Synopsis
- The study examined how errors in the positioning of prostate cancer patients during radiation therapy (both between treatment sessions and during a single session) affect the distribution of the radiation dose, particularly focusing on carbon-ion beam therapy.
- Researchers tracked the positions of gold markers implanted in the patients to identify discrepancies in positioning and assessed how these errors impacted the planned radiation dose distribution.
- Results showed that aligning treatment based on the fiducial markers significantly improved the coverage of the target treatment area, ensuring that a higher percentage of the prescribed dose reached the cancerous tissue compared to traditional skeletal matching methods.
A Single-Institution Prospective Study To Evaluate the Safety and Efficacy of Real- Time Image-Gated Spot-Scanning Proton Therapy (RGPT) for Prostate Cancer.
Adv Radiat Oncol
May 2024
Department of Radiation Oncology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Purpose: In real-time image-gated spot-scanning proton therapy (RGPT), the dose distribution is distorted by gold fiducial markers placed in the prostate. Distortion can be suppressed by using small markers and more than 2 fields, but additional fields may increase the dose to organs at risk. Therefore, we conducted a prospective study to evaluate the safety and short-term clinical outcome of RGPT for prostate cancer.
View Article and Find Full Text PDFSampling of microplastics at a materials recovery facility.
Anal Bioanal Chem
May 2024
Materials Measurement Science Division, National Institute of Standards and Technology, Gaithersburg, MD, USA.
Detecting, separating, and characterizing airborne microplastics from other airborne particulates is currently challenging due to the various instrumental constraints and related sample preparation hurdles that must be overcome. The ability to measure these real-world environments is needed to better assess the risks associated with microplastics. To that end, the current study focused on developing a methodology for sampling and characterizing airborne microplastics.
View Article and Find Full Text PDFCarbon-Iodine Polydiacetylene Nanofibers for Image-Guided Radiotherapy and Tumor-Microenvironment-Enhanced Radiosensitization.
ACS Nano
March 2024
Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Radiotherapy is a mainstay treatment used in clinics for locoregional therapy, although it still represents a great challenge to improve the sensitivity and accuracy of radiotherapy for tumors. Here, we report the conjugated polymer, polydiiododiacetylene (PIDA), with an iodine content of 84 wt %, as a highly effective computed tomography (CT) contrast agent and tumor microenvironment-responsive radiosensitizer. PIDA exhibited several key properties that contribute to the improvement of precision radiotherapy.
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