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Association between health status and long-term mortality after percutaneous revascularization of peripheral artery disease. | LitMetric

AI Article Synopsis

  • The study aimed to investigate the link between changes in health status and long-term survival in patients with symptomatic peripheral artery disease (PAD) after endovascular therapy (EVT).
  • Results showed that 79% of patients experienced significant health improvements one year post-procedure, and these "responders" had a much better 10-year survival rate (60%) compared to nonresponders (38%).
  • The findings suggest that enhancing health status after EVT may lead to better long-term survival outcomes, indicating a need for further research on treatments for patients who do not respond well to EVT.

Article Abstract

Objectives: To explore the association of health status change and long-term survival among patients with symptomatic peripheral artery disease (PAD).

Background: Early gains in health status after successful endovascular therapy (EVT) for symptomatic PAD can be maintained up to 1 year. Whether such health status improvements are associated with long-term survival benefits is unknown.

Methods: Between February 2001 and August 2004, 258 patients with symptomatic PAD treated with EVT participated in a prospective study evaluating baseline and 1 year health status using the Peripheral Artery Questionnaire (range 0-100, higher scores = better). All-cause mortality was assessed for all patients at a median of 9.4 years following EVT.

Results: The mean age at enrollment was 68 ± 11 years; 61% were male, 97% were Caucasian, and 38% had diabetes. Patients with a clinically meaningful health status improvement (≥8 points) 1 year after their index procedure (79%) were identified as responders. Responders had a significantly better 10 year survival compared with nonresponders (60% vs 38%, p = 0.025). Responder status was associated with a survival advantage that persisted in risk-adjusted analysis (adjusted hazard ratio for long-term mortality, 0.66 [95% CI, 0.45-0.97]; p = 0.036).

Conclusions: Among patients with symptomatic PAD undergoing EVT, improvement of PAD-specific health status at 1 year follow-up was associated with improved long-term survival. Whether additional treatment for patients with poor response to EVT could improve long-term survival warrants further investigation. © 2016 Wiley Periodicals, Inc.

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Source
http://dx.doi.org/10.1002/ccd.26442DOI Listing

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