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An Analysis of Percutaneous Nephrolithotomy (PCNL) Performed at the Institute of Kidney Disease, Pakistan: Stone Clearance and Complications.
Cureus
December 2024
Department of Cardiovascular Medicine, Khyber Medical Institute of Medical Sciences, Kohat, PAK.
Background: Percutaneous nephrolithotomy (PCNL) is the preferred treatment for large renal stones, yet variability in outcomes arises from patient-specific factors and institutional practices. Understanding complications and predictors of success is essential to improving procedural efficacy.
Objective: This study aimed to evaluate stone clearance rates, complications classified using the Clavien-Dindo system, and predictors of PCNL outcomes, with a focus on improving lower calyx stone clearance.
Pediatric Nephrolithiasis: A Changing Landscape Through Time and Space.
Medicina (Kaunas)
December 2024
Pediatric Unit, Department of Surgical Sciences, Destiny, Gynecology and Pediatrics, University of Verona, 37126 Verona, Italy.
Pediatric nephrolithiasis is an ancient and complex disorder that has seen a significant rise in recent decades and the underlying causes contributing to stone formation in children may also be shifting. Historically, kidney stones have been linked to factors such as metabolic disorders, congenital abnormalities, and family history. However, the recent increase in incidence appears to be associated with new risk factors, including changes in lifestyle and diet, the growing prevalence of obesity, metabolic syndrome, diabetes, and even climate change.
View Article and Find Full Text PDFIdentifying Risk Factors for Urinary Tract Stones in Pregnant Women at a Tertiary Hospital in China: A Retrospective Survey.
Arch Esp Urol
December 2024
Obstetrics and Gynecology Department, Anhui Wannan Rehabilitation Hospital (The Fifth People's Hospital of Wuhu), 241000 Wuhu, Anhui, China.
Background: Urinary tract stones present significant health risks to pregnant women and their foetuses. However, the specific risk factors contributing to stone formation during pregnancy, particularly within the Chinese population, remain poorly understood. This retrospective survey aimed to identify demographic, clinical, and obstetric risk factors associated with urinary tract stones in pregnant women at a tertiary hospital in China.
View Article and Find Full Text PDFIGF1R Enhances Calcium Oxalate Monohydrate-Induced Epithelial-Mesenchymal Transition by Reprogramming Metabolism via the JAK2/STAT3 Signaling.
Int J Biol Sci
January 2025
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Kidney stone disease is a major risk factor for impaired renal function, leading to renal fibrosis and end-stage renal disease. High global prevalence and recurrence rate pose a significant threat to human health and healthcare resources. Investigating the mechanisms of kidney stone-induced injury is crucial.
View Article and Find Full Text PDFSulfated Polysaccharides Inhibit CaOx Stone Formation by Inhibiting Calcium Oxalate Crystallization, Cellular Inflammation, and Crystal Adhesion.
J Agric Food Chem
December 2024
Institute of Biomineralization and Lithiasis Research, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
Hyperoxaluria can easily induce calcium oxalate (CaOx) crystals and cause cell damage, thereby increasing the risk of kidney stone formation. In this study, three sulfated polysaccharides (PSPs) were obtained by the sulfur trioxide-pyridine method. The antioxidant activity of PSPs and the inhibitory effects of PSPs on CaOx crystallization, cellular oxidative damage, and cellular inflammation were explored in vitro, and PSPs were used to treat hyperoxaluria-induced crystallization model mice in order to validate the stone-preventive effect of PSPs in vivo.
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