AI Article Synopsis
- Researchers developed a new method for combining alkynes through a highly selective reaction that uses dual gold and photoredox catalysis activated by visible light.
- This process allows for simultaneous oxidation of gold and coordination with coupling partners, achieving high selectivity for desired products while minimizing unwanted side reactions.
- The approach has been successfully applied in various arylative reactions and hydration reactions, expanding the applicability of gold catalysts and emphasizing the benefits of using mild, environmentally friendly visible-light activation.
Article Abstract
Highly selective tandem nucleophilic addition/cross-coupling reactions of alkynes have been developed using visible-light-promoted dual gold/photoredox catalysis. The simultaneous oxidation of Au(I) and coordination of the coupling partner by photo-generated aryl radicals, and the use of catalytically inactive gold precatalysts allows for high levels of selectivity for the cross-coupled products without competing hydrofunctionalization or homocoupling. As demonstrated in representative arylative Meyer-Schuster and hydration reactions, this work expands the scope of dual gold/photoredox catalysis to the largest class of substrates for gold catalysts and benefits from the mild and environmentally attractive nature of visible-light activation.
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| http://dx.doi.org/10.1002/chem.201600710 | DOI Listing |
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