AI Article Synopsis
- The study aimed to create a method for measuring the levels of 8 carbamate pesticides in urine samples simultaneously.
- Urine samples were processed using liquid chromatography-tandem mass spectrometry, with results showing good linearity and recovery rates at varying concentrations.
- The method complies with occupational health standards and is suitable for testing patients suspected of pesticide poisoning.
Article Abstract
Objective: To establish a method for simultaneously determining the urinary concentrations of 8 carbamate pesticides.
Methods: After being purified by acetonitrile precipitation, urine samples were transferred to a liquid chromatography-tandem mass spectrometry system, and the concentrations of 8 carbamate pesticides were determined by external standard method. A C18 column was used for ultra-high-performance liquid chromatography; methanol/ammonium acetate solution was used as the mobile phase for gradient elution; the mass spectrometer was operated in a multi-reaction monitoring mode.
Results: The calibration curves were linear when the urinary concentrations of these carbamate pesticides were 20~800 µg/L, and the recovery rates were 61.0%~121% at spiked levels of 20, 200 and 800 µg/L, with a relative standard deviation of 1.7%~5.5%.
Conclusion: This determination method meets the Guide for establishing occupational health standards-part 5: Determination methods of chemicals in biological materials, and can be used for simultaneous determination of 8 carbamate pesticides in the urine of poisoning patients.
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