Kinetic Diversity of Striatal Dopamine: Evidence from a Novel Protocol for Voltammetry.

ACS Chem Neurosci

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

Published: May 2016

In vivo voltammetry reveals substantial diversity of dopamine kinetics in the rat striatum. To substantiate this kinetic diversity, we evaluate the temporal distortion of dopamine measurements arising from the diffusion-limited adsorption of dopamine to voltammetric microelectrodes. We validate two mathematical procedures for correcting adsorptive distortion, both of which substantiate that dopamine's apparent kinetic diversity is not an adsorption artifact.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschemneuro.6b00020DOI Listing

Publication Analysis

Top Keywords

kinetic diversity
12
diversity striatal
4
dopamine
4
striatal dopamine
4
dopamine evidence
4
evidence novel
4
novel protocol
4
protocol voltammetry
4
voltammetry vivo
4
vivo voltammetry
4

Similar Publications

Planar chirality found tremendous use in many fields, such as chemistry, optics, and materials science. In particular, planar chiral [2.2]paracyclophanes (PCPs) are a type of structurally interesting and practically useful chiral compounds bearing unique electronic and photophysical properties and thus have been widely used in π-stacking polymers, organic luminescent materials, and as a valuable toolbox for developing chiral ligands or organocatalysts.

View Article and Find Full Text PDF

The majority of enantioselective organocatalytic reactions occur in apolar or weakly polar organic solvents. Nevertheless, the influence of solute-solvent van der Waals forces on the relative kinetics of competitive pathways remains poorly understood. In this study, we provide a first insight into the nature and strength of these interactions at the transition state level using advanced computational tools, shedding light into their influence on the selectivity.

View Article and Find Full Text PDF

Temperature-Directed Morphology Transformation Method for Precision-Engineered Polymer Nanostructures.

ACS Nano

January 2025

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia.

With polymer nanoparticles now playing an influential role in biological applications, the synthesis of nanoparticles with precise control over size, shape, and chemical functionality, along with a responsive ability to environmental changes, remains a significant challenge. To address this challenge, innovative polymerization methods must be developed that can incorporate diverse functional groups and stimuli-responsive moieties into polymer nanostructures, which can then be tailored for specific biological applications. By combining the advantages of emulsion polymerization in an environmentally friendly reaction medium, high polymerization rates due to the compartmentalization effect, chemical functionality, and scalability, with the precise control over polymer chain growth achieved through reversible-deactivation radical polymerization, our group developed the temperature-directed morphology transformation (TDMT) method to produce polymer nanoparticles.

View Article and Find Full Text PDF

Research is ongoing to develop new phosphors capable of emitting light across a broad spectrum, ranging from the ultraviolet (UV) to the infrared region, with potential applications in diverse fields. Using the method of solid-state reactions, a series of LiBaF:Pr phosphors were obtained, and their luminescent properties in the UV-visible range were studied. The photon cascade emission (PCE) phenomenon has been observed under excitation of the 4f5d bands of Pr.

View Article and Find Full Text PDF

How hydrodynamic conditions drive the regime shift towards a bacterial state with lower carbon emissions in river bends.

Environ Res

January 2025

Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, College of Environment, Hohai University, Nanjing 210098, P.R. China.

Hydrodynamic conditions influenced by river sinuosity may alter carbon (e.g., carbon dioxide and methane) emissions and microbial communities responsible for nutrient turnover.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!