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The Molecular Bases of Anti-Oxidative and Anti-Inflammatory Properties of Paraoxonase 1.
Antioxidants (Basel)
October 2024
Department of Biochemistry and Biotechnology, University of Life Sciences, 60-637 Poznań, Poland.
The anti-oxidative and anti-inflammatory properties of high-density lipoprotein (HDL) are thought to be mediated by paraoxonase 1 (PON1), a calcium-dependent hydrolytic enzyme carried on a subfraction of HDL that also carries other anti-oxidative and anti-inflammatory proteins. In humans and mice, low PON1 activity is associated with elevated oxidized lipids and homocysteine (Hcy)-thiolactone, as well as proteins that are modified by these metabolites, which can cause oxidative stress and inflammation. PON1-dependent metabolic changes can lead to atherothrombotic cardiovascular disease, Alzheimer's disease, and cancer.
View Article and Find Full Text PDFButyrate-Mediated Modulation of Paraoxonase-1 Alleviates Cardiorenometabolic Abnormalities in a Rat Model of Polycystic Ovarian Syndrome.
Cardiovasc Drugs Ther
November 2024
Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Article Synopsis
- Polycystic ovarian syndrome (PCOS) is linked to increased cardiovascular risks and cardiorenal disorders, and the study explores how short-chain fatty acids (SCFAs), particularly butyrate, may influence these conditions.
- * The research involved administering letrozole to induce PCOS in rats, followed by treatment with butyrate, leading to observations of various metabolic, cardiac, and renal abnormalities in PCOS rats.
- * Results indicated that butyrate treatment significantly improved systemic and cardiorenal health markers while boosting paraoxonase-1 (PON-1) levels, suggesting its potential as a therapeutic option for managing heart and kidney issues in PCOS.
Gestational organophosphate pesticide exposure and childhood cardiovascular outcomes.
Environ Int
November 2024
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, NC, United States. Electronic address:
Introduction: The general population is chronically exposed to organophosphate pesticides through various routes including ingestion, hand-to-mouth contact, inhalation, and dermal contact. Exposure to organophosphate pesticides during pregnancy impairs fetal development, but the potential long-term effects of gestational organophosphate pesticide exposure are less well understood.
Methods: We investigated associations between gestational organophosphate pesticide exposure and cardiovascular outcomes in 643 children in the Generation R Study, a prospective pregnancy cohort based in Rotterdam, The Netherlands.
Exploring the protective role of green tea extract against cardiovascular alterations induced by chronic REM sleep deprivation via modulation of inflammation and oxidative stress.
BMC Complement Med Ther
October 2024
Private Practice, Otorhinolaryngology, İstanbul, 34360, Turkey.
Background: Chronic Rapid eye movement (REM) sleep deprivation has been associated with various cardiovascular alterations, including disruptions in antioxidant defense mechanisms, lipid metabolism, and inflammatory responses. This study investigates the therapeutic potential of green tea extract (GTE) in mitigating these adverse effects.
Methods: A total of 24 male Wistar albino rats were used in this study and divided into the control group (n = 8), Chronic-REM Sleep Deprivation (CRSD) Group (n = 8) and Chronic-REM SD + Green Tea 200 (CRSD + GTE200) Group (n = 8).
Increased oxidative stress biomarkers in central serous chorioretinopathy.
Sci Rep
September 2024
Department of Ophthalmology, Antalya Akseki State Hospital, 07050, Antalya, Turkey.
Article Synopsis
- * The study analyzed serum samples from 33 patients with treatment-naïve acute CSC and 35 healthy controls, measuring various oxidative stress and lipoprotein markers.
- * Results showed that patients with acute CSC had higher levels of oxidative stress markers and lower HDL functionality than controls, revealing a link that could aid in diagnosing and treating CSC.
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