The association between transforming growth factor-β1 (TGF-β1) polymorphisms with the risk of diabetes mellitus (DM) remains elusive. We aimed to evaluate the relationship between TGF-β1 polymorphisms and DM risk. We searched the association studies according to a predefined criteria using electronic databases. The strength of association between TGF-β1 codon 10/25 polymorphisms and the risk of DM was evaluated by odds ratio (OR) with the corresponding 95% confidence interval (CI). Six case-control studies were identified for the analysis of the association between TGF-β1 codon 10/25 polymorphism and the risk of DM. CC genotype at the codon 10 polymorphism was associated with the risk of type 2 DM (T2DM) (P = 0.026, OR = 1.397, 95% CI = 1.041-1.874). No marked association was observed between codon 25 polymorphism and the risk of DM. No evidence of marked publication bias was observed. CC genotype at the TGF-β1 codon 10 site may be an indicator for the risk of T2DM. However, further larger studies should be performed in the future.
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