AI Article Synopsis
- The paper examines the connection between late onset hypogonadism (LOH) and common health issues, particularly metabolic diseases, while evaluating the pros and cons of testosterone replacement therapy (TRT).
- Findings indicate that LOH is linked to poorer metabolic health and increased risk of cardiovascular problems, with a complicated relationship between hypogonadism, obesity, and insulin resistance.
- The authors suggest that TRT may improve body composition and metabolic health in those with LOH, but caution that more long-term research is needed to fully understand the relationship between low testosterone and aging-related health issues.
Article Abstract
Background: The aim of this paper is to summarize the available evidence supporting the link between late onset hypogonadism (LOH) and associated common clinical illnesses, focusing on metabolic diseases. The possible benefits or risks related to testosterone replacement therapy (TRT) in these conditions will also be analyzed.
Methods: An extensive Medline search was performed.
Results: LOH is closely associated with a worse metabolic profile and a higher cardiovascular risk. The relationship between hypogonadism obesity and insulin resistance is complex and bidirectional. Emerging evidence suggests a positive role of TRT in improving body composition and metabolic outcomes in subjects with LOH.
Conclusions: Despite the aforementioned data, it is not completely known whether reduced testosterone levels in elderly males might play a direct pathogenetic role in these conditions or whether low T and associated morbidities are concomitant conditions, both associated with the aging process. Further and longer studies are advisable to confirm the preliminary results.
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