Objective: The aim of the study was to estimate the neoplastic potential of vulvar lichen sclerosus (VLS).
Materials And Methods: This was a retrospective study of 976 women with VLS. We recorded age at diagnosis of VLS, length of follow-up, and type of neoplasia, categorized as the following: (1) vulvar intraepithelial neoplasia (VIN), further subdivided in differentiated VIN (dVIN) and high-grade squamous intraepithelial lesion; (2) superficially invasive squamous cell carcinoma; and (3) frankly invasive squamous cell carcinoma. Neoplasia incidence risk, neoplasia incidence rate, and cumulative probability of progression to neoplasia according to the Kaplan-Meier method were estimated. Log-rank test was used to compare the progression-free survival curves by age at diagnosis of VLS.
Results: The mean age at diagnosis of VLS was 60 (median = 60; range = 8-91) years. The mean length of follow-up was 52 (median = 21; range = 1-331) months. The following 34 patients developed a neoplasia: 8 VIN (4 dVIN, 4 high-grade squamous intraepithelial lesions), 6 keratinizing superficially invasive squamous cell carcinoma (5 with adjacent dVIN), and 20 keratinizing invasive squamous cell carcinoma (1 with adjacent dVIN). The neoplasia incidence risk was 3.5%. The neoplasia incidence rate was 8.1 per 1,000 person-years. The cumulative probability of progression to neoplasia increased from 1.2% at 24 months to 36.8% at 300 months. The median progression-free survival was significantly shorter in older women (≥70 years) when compared with that in younger women (p = .003).
Conclusions: Vulvar lichen sclerosus has a nonnegligible risk of neoplastic transformation and requires a careful and lifelong follow-up in all patients, particularly in elderly women. Early clinical and histological detection of preinvasive lesions is essential to reduce the risk of vulvar cancer.
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http://dx.doi.org/10.1097/LGT.0000000000000186 | DOI Listing |
Head Neck Pathol
January 2025
Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Purpose: Oral squamous cell carcinoma (OSCC) is a significant public health challenge associated with high mortality rates primarily due to its invasive and metastatic behavior. This study aimed to evaluate the expression patterns of five critical biomarkers: β-catenin, E-cadherin, podoplanin (PDPN), CXCR4, and p53 in OSCC tissues and to investigate their correlations with clinicopathologic features and patient outcomes.
Methods: We conducted an immunohistochemical analysis utilizing tissue microarrays (TMAs) from 95 patients diagnosed with primary OSCC.
Mol Carcinog
January 2025
Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, ZhengZhou, China.
Esophageal squamous cell carcinoma (ESCC) is one of the main subtypes of esophageal carcinoma with high morbidity. This study aimed to explore the role of FKBP prolyl isomerase 11 (FKBP11) in ESCC and investigate the underlying mechanism. FKBP11 levels in ESCC tumor tissues and cell lines were measured.
View Article and Find Full Text PDFBraz Oral Res
December 2024
Universidade Estadual de Campinas - Unicamp, Piracicaba Dental School, Dnepartment of Oral Diagnosis, Piracicaba, SP, Brazil.
The aim of this study was to perform a clinicopathological analysis of oral squamous cell carcinoma (OSCC) in young patients from the northeast of Brazil and compare with elderly individuals. This retrospective study reviewed 104 OSCC cases from 2000 to 2015, focusing on patients under 40 and over 60 at diagnosis. Forty-two patients under 40 years old (40.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Otolaryngology, the First Affiliated Hospital of Xinxiang Medical University, No. 88, Jiankang Road, Xinxiang, Henan, 453100, China.
High levels of the N7 methylguanosine (m7G) methyltransferase WD repeat domain 4 (WDR4) are associated with the progression of multiple tumors, including head and neck squamous cell carcinoma. Laryngeal cancer (LC) is the second most common malignant tumor of the head and neck. However, the role of WDR4 in LC remains unclear.
View Article and Find Full Text PDFNeuroradiol J
January 2025
Division of Neurological Radiology, Department of Diagnostic and Therapeutic Radiology, Ramathibodi Hospital, Mahidol University, Thailand.
Dual-energy CT (DECT), also known as spectral CT, has advanced diagnostic capabilities in head and neck pathologies beyond those of conventional single-energy CT (SECT). By having images at two distinct energy levels, DECT generates virtual monoenergetic images (VMIs), iodine maps, and quantitative features such as iodine concentration (IC) and spectral Hounsfield unit attenuation curves (SHUAC), which leads to enhancing tissue characterization, reducing artifacts, and differentiating head and neck pathologies. This review highlights DECT's applications in evaluating head and neck squamous cell carcinoma (SCC), thyroid cartilage invasion, cervical lymph node metastasis, radiation therapy planning, post-treatment assessment, and role in other head and neck conditions, such as infection and sialolithiasis.
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