AI Article Synopsis
- * Noxious thermal stimuli lead to a unique response pattern in Class IV neurons, characterized by pauses after high-frequency activity and a significant increase in calcium ions (Ca(2+)) in the dendrites.
- * The study suggests that the influx of Ca(2+) is crucial for encoding thermal sensations, indicating its role in enhancing heat avoidance behavior.
Article Abstract
Adequate responses to noxious stimuli causing tissue damages are essential for organismal survival. Class IV neurons in Drosophila larvae are polymodal nociceptors responsible for thermal, mechanical, and light sensation. Importantly, activation of Class IV provoked distinct avoidance behaviors, depending on the inputs. We found that noxious thermal stimuli, but not blue light stimulation, caused a unique pattern of Class IV, which were composed of pauses after high-frequency spike trains and a large Ca(2+) rise in the dendrite (the Ca(2+) transient). Both these responses depended on two TRPA channels and the L-type voltage-gated calcium channel (L-VGCC), showing that the thermosensation provokes Ca(2+) influx. The precipitous fluctuation of firing rate in Class IV neurons enhanced the robust heat avoidance. We hypothesize that the Ca(2+) influx can be a key signal encoding a specific modality.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786431 | PMC |
| http://dx.doi.org/10.7554/eLife.12959 | DOI Listing |
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