Replication and spread of human viruses is based on the simultaneous exploitation of many different host functions, bridging multiple scales in space and time. Mathematical modeling is essential to obtain a systems-level understanding of how human viruses manage to proceed through their life cycles. Here, we review corresponding advances for viral systems of large medical relevance, such as human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV). We will outline how the combination of mathematical models and experimental data has advanced our quantitative knowledge about various processes of these pathogens, and how novel quantitative approaches promise to fill remaining gaps.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/1873-3468.12095 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Stochastic games of parental vaccination decision making and bounded rationality.
Math Biosci Eng
February 2025
School of Mathematical and Statistical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, Texas, USA.
Vaccination is an effective strategy to prevent the spread of diseases. However, hesitancy and rejection of vaccines, particularly in childhood immunizations, pose challenges to vaccination efforts. In that case, according to rational decision-making and classical utility theory, parents weigh the costs of vaccination against the costs of not vaccinating their children.
View Article and Find Full Text PDFThe loss of both pUL16 and pUL21 in HSV-1-infected cells alters capsid-tegument composition, nuclear membrane architecture, cytoplasmic maturation and cell-to-cell spread.
J Gen Virol
March 2025
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Previously, we had developed synthetic genomics methods to assemble an infectious clone of herpes simplex virus type-1 (HSV-1) strain KOS. To do this, the genome was assembled from 11 separate cloned fragments in yeast using transformation-associated recombination. Using this method, we generated null mutations in five tegument protein-coding genes as well as different combinations of these mutants.
View Article and Find Full Text PDFMorpho-molecular identification of causing anthracnose disease of banana in Pakistan.
Plant Dis
March 2025
College of science, King Saud University, Department of Botany and Microbiology, Riyadh, Riyadh, Saudi Arabia;
Banana (Musa spp.) is widely cultivated as the major fruit in Pakistan. Anthracnose fruit rot caused by various Colletotrichum spp.
View Article and Find Full Text PDFUnderrated risk of antibiotic resistance genes dissemination mediated by bioaerosols released from anaerobic biological wastewater treatment system.
Water Res
March 2025
School of Engineering, Hangzhou Normal University, Hangzhou 311121, PR China.
Antibiotic resistance has been recognized as one of the most prevalent public health problems. The bioaerosol-mediated spread of antibiotic resistance genes (ARGs) is an important but underrated pathway. Therefore, this work investigated the comprehensive resistome and pathogen-induced risk in bioaerosols released from anaerobic ammonium oxidation (anammox) process under antibiotic stress.
View Article and Find Full Text PDFAutophagy and Programmed Cell Death Modalities Interplay in HIV Pathogenesis.
Cells
February 2025
Departmental Faculty of Medicine, Saint Camillus International University of Health Sciences, 00131 Rome, Italy.
Human immunodeficiency virus (HIV) infection continues to be a major global health challenge, affecting 38.4 million according to the Joint United Nations Program on HIV/AIDS (UNAIDS) at the end of 2021 with 1.5 million new infections.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!