The development of enantioselective, copper-catalyzed alkynylations of cyclic iminium and oxocarbenium ions is reviewed. The use of chiral copper-based catalysts has enabled high yields and enantioselectivites in the formation of nitrogen- and oxygen-containing heterocycles with α-stereogenic centers. This review highlights both the accomplishments and the future work needed in this important area.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734405 | PMC |
| http://dx.doi.org/10.3762/bjoc.11.290 | DOI Listing |
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