Theophylline poisoning long has been recognized as difficult to treat and still has an over-all mortality rate of about 10%. In recent years, the increasing use of sustained-release preparations has changed the pattern of toxicity. The management of theophylline toxicity is compounded by clinical differences between chronic (overmedication) intoxication and acute single ingestions of a large amount of the drug, inter- and intraindividual variability in theophylline metabolism and dose-dependent kinetics in poisoned patients. Management decisions should be based on both clinical assessment and laboratory information (particularly theophylline concentrations).
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| http://dx.doi.org/10.5694/j.1326-5377.1989.tb139649.x | DOI Listing |
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