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Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit.
Nat Commun
January 2025
Neuronal Cell Biology Division, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38104, USA.
Exiting a germinal zone (GZ) initiates a cascade of events that promote neuronal maturation and circuit assembly. Developing neurons and their progenitors must interpret various niche signals-such as morphogens, guidance molecules, extracellular matrix components, and adhesive cues-to navigate this region. How differentiating neurons in mouse brains integrate and adapt to multiple cell-extrinsic niche cues with their cell-intrinsic machinery in exiting a GZ is unknown.
View Article and Find Full Text PDFUF-5000 urinary erythrocyte parameters versus urinary aberrant erythrocytes and acanthocytes for diagnosing IgA glomerular hematuria.
Sci Rep
January 2025
Clinical Laboratory, Dongyang People's Hospital, No. 60 Wuning West Road, Dongyang City, 322100, Zhejiang, China.
This study evaluated the diagnostic value of the automated UF-5000 parameters and compared it with that of aberrant erythrocytes and acanthocytes classified by microscopy for identifying IgA glomerular hematuria to propose a predictive model for clinical use. It also compared correlations between erythrocyte parameters and malformed erythrocytes. Urine samples from 53 biopsy-proven IgA hematuria cases and 143 non-IGA nephropathic hematuria cases as controls were analyzed.
View Article and Find Full Text PDFA real-world disproportionality analysis of colchicine: data mining of the public version of FDA Adverse Event Reporting System.
Expert Opin Drug Saf
December 2024
Department of Cardiology, Intervention Cardiology Center, Wuhan No.1 Hospital, Wuhan, China.
Background: Colchicine is widely used for gout and familial Mediterranean fever (FMF) and has cardiovascular benefits. However, it is linked to various adverse drug reactions (ADRs). This study aimed to analyze colchicine-related ADRs using FAERS data for safer clinical use.
View Article and Find Full Text PDFDual BACH1 regulation by complementary SCF-type E3 ligases.
Cell
December 2024
Discovery Sciences, Novartis Biomedical Research, Basel, Switzerland. Electronic address:
Broad-complex, tramtrack, and bric-à-brac domain (BTB) and CNC homolog 1 (BACH1) is a key regulator of the cellular oxidative stress response and an oncogene that undergoes tight post-translational control by two distinct F-box ubiquitin ligases, SCF and SCF. However, how both ligases recognize BACH1 under oxidative stress is unclear. In our study, we elucidate the mechanism by which FBXO22 recognizes a quaternary degron in a domain-swapped β-sheet of the BACH1 BTB dimer.
View Article and Find Full Text PDFRegulating Zn deposition via an ion-sieving, nanoporous cellulose separator for high performance aqueous zinc-ion batteries.
Int J Biol Macromol
December 2024
Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Jinan, 250353, Shandong, PR China.
Aqueous zinc-ion batteries (AZIBs), one of the most promising renewable energy storage devices, are largely impeded by the disreputable cycling stability in its large-scale application as a result of the undesirable Zn dendrites growth and the side reactions. In this context, a carboxylate (-COO) anionic group functionalized cellulose nanofibrils separator (A-CNF) with nanoporous structure and ion-sieving effect is developed to realize a stable Zn anode without dendrites and by-products. An increased Zn transference number and uniform Zn deposition can be achieved through the electrostatic adsorption between -COO and Zn.
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