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JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain.
Acta Neuropathol Commun
December 2024
Laboratory of Stem Cell Biology and Epigenetics, School of Basic Medical Sciences, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
Midbrain dopamine (mDA) neurons participate in a wide range of brain functions through an intricate regulation of DA biosynthesis. The epigenetic factors and mechanisms in this process are not well understood. Here we report that histone demethylase JMJD3 is a critical regulator for DA biosynthesis in adult mouse mDA neurons.
View Article and Find Full Text PDFTranscriptomic Profiling Reveals Sex-Specific Epigenetic Dynamics Involving kdm6b and H3K27 Methylation in Cerebral Ischemia-Induced Neurogenesis and Recovery.
Neuromolecular Med
November 2024
Applied Biology, CSIR-Indian Institute of Chemical Technology (IICT), Tarnaka, Hyderabad, 500007, India.
Cerebral ischemic stroke ranks among the leading causes of death and disability worldwide. A significant challenge, beyond the lack of effective therapies, is the frequent oversight of sex as a vital factor in stroke research. This study focuses on elucidating the sex-specific epigenetic mechanisms that contribute to neural damage and recovery in cerebral ischemia.
View Article and Find Full Text PDF[Effect of JMJD3-IRF4 Signaling Pathway-Mediated Macrophage Polarization on the Malignant Biological Behavior of Multiple Myeloma Cells].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2024
Department of Laboratory Medicine, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang 550014, Guizhou Province, China.
Article Synopsis
- The research aims to explore how the JMJD3-IRF4 signaling pathway affects macrophage polarization and the aggressive behavior of multiple myeloma (MM) cells.
- The study involves differentiating THP-1 monocytes into various macrophage groups and examining changes in specific protein levels and cell behaviors like proliferation, apoptosis, migration, and invasion.
- Results show that M2 macrophages stimulated proliferation and clone formation of MM cells while increasing specific markers (like CD206 and Arg-1) and cytokines (IL-10 and TGF-β), indicating that this polarization plays a significant role in MM malignancy.
Understanding the Role of the SMN Complex Component GEMIN5 and Its Functional Relationship with Demethylase KDM6B in the Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal Muscular Atrophy.
Int J Mol Sci
September 2024
T3S, INSERM UMR1124, Faculté des Sciences Fondamentales et Biomédicales, Université Paris Cité, F-75006 Paris, France.
Dysregulated RNA metabolism caused by SMN deficiency leads to motor neuron disease spinal muscular atrophy (SMA). Current therapies improve patient outcomes but achieve no definite cure, prompting renewed efforts to better understand disease mechanisms. The calcium channel blocker flunarizine improves motor function in -deficient mice and can help uncover neuroprotective pathways.
View Article and Find Full Text PDFEmerging role of Jumonji domain-containing protein D3 in inflammatory diseases.
J Pharm Anal
September 2024
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang, 315211, China.
Jumonji domain-containing protein D3 (JMJD3) is a 2-oxoglutarate-dependent dioxygenase that specifically removes transcriptional repression marks di- and tri-methylated groups from lysine 27 on histone 3 (H3K27me2/3). The erasure of these marks leads to the activation of some associated genes, thereby influencing various biological processes, such as development, differentiation, and immune response. However, comprehensive descriptions regarding the relationship between JMJD3 and inflammation are lacking.
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