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"Want" Is a Four-Letter Word in End-of-Life Communication.
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1 Indiana University School of Medicine Indianapolis, Indiana.
RNA secondary structure design.
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We consider the inverse-folding problem for RNA secondary structures: for a given (pseudo-knot-free) secondary structure we want to find a sequence that has a certain structure as its ground state. If such a sequence exists, the structure is called designable. We have implemented a branch-and-bound algorithm that is able to do an exhaustive search within the sequence space, i.
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