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| http://dx.doi.org/10.1164/rccm.201509-1872LE | DOI Listing |
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RS35705950 polymorphism of MUC5B Gene: Association with Rheumatoid Arthritis and Interstitial lung disease in Tunisian Population.
Tunis Med
December 2024
University of Sousse, Faculty of Medicine of Sousse, Rheumatology Department, Farhat Hached Hospital, Sousse, Tunisia.
Introduction: Interstitial lung disease (ILD) is the most common extra-articular manifestation in rheumatoid arthritis (RA). Studies have concluded that there is an association between rs35705950 polymorphism of the MUC5B gene and RA-ILD.
Aim: To explore this polymorphism in a cohort of Tunisian patients suffering from RA with or without ILD and stufdy its association to ILD during RA.
The impact of genetic polymorphism on course and severity of the SARS-CoV-2 infection and COVID-19 disease.
Przegl Epidemiol
December 2024
Klinika Chorób Zakaźnych i Neuroinfekcji, Uniwersytet Medyczny w Białymstoku.
COVID-19 is severe respiratory and systemic disease with complex pathogenesis and many clinical symptoms, including symptoms from respiratory system, immunology system, cardio-vascular system, haematopoietic system and neurological system. Severe character of the disease is associated with occurrence of respiratory failure, septic shock, multiple organ dysfunctions syndrome, which can lead to patients death due to cardiac arrest. Knowledge about interactions between the virus and human proteins as well as knowledge of immunological mechanisms against infection is a key to identifying the area of virus activity and severity factors of COVID-19.
View Article and Find Full Text PDFDivergence in Regulatory Regions and Gene Duplications May Underlie Chronobiological Adaptation in Desert Tortoises.
Mol Ecol
January 2025
Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Many cellular processes and organismal behaviours are time-dependent, and asynchrony of these phenomena can facilitate speciation through reinforcement mechanisms. The Mojave and Sonoran desert tortoises (Gopherus agassizii and G. morafkai respectively) reside in adjoining deserts with distinct seasonal rainfall patterns and they exhibit asynchronous winter brumation and reproductive behaviours.
View Article and Find Full Text PDFMiddle Ear microRNAs Drive Mucin Gene Response.
Laryngoscope
November 2024
Division of Otolaryngology, Sheikh Zayed Center for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
Objective(s): To investigate the role of microRNA-378 (miR-378) in the regulation of mucin gene expression and inflammatory response in human middle ear epithelial cells (HMEEC) during bacterial infection by non-typeable Haemophilus influenzae (NTHi).
Methods: Human middle ear epithelial cells (HMEEC) were cultured and transfected with miR-378 or control miRNA. Post-transfection, cells were exposed to NTHi lysates.
Long-Term Air Pollution Exposure and Severity of Idiopathic Pulmonary Fibrosis: Data from the IPF-PRO Registry.
Ann Am Thorac Soc
November 2024
Yale School of Medicine, New Haven, Connecticut, United States.
Rationale: While exposure to air pollution is a known risk factor for adverse pulmonary outcomes, its impact in individuals with idiopathic pulmonary fibrosis (IPF) is less well understood.
Objective: To investigate the effects of long-term exposure to air pollution on disease severity and progression in patients with IPF and to determine whether genomic factors, such as MUC5B promoter polymorphism or telomere length, modify these associations.
Methods: We performed analyses at enrollment and after one year of follow-up in the IPF-PRO Registry, a prospective observational registry that enrolled individuals with IPF at 46 US sites from June 2014 to October 2018.
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