AI Article Synopsis
- Granulomatous dermatoses are common skin issues requiring histopathological confirmation, with six identified sub-types of granulomas.
- A five-year retrospective study analyzed 1,280 skin biopsies, revealing 186 cases of granulomatous lesions, with tuberculoid granuloma being the most prevalent and leprosy as the leading cause.
- Histopathological examination is crucial for accurately diagnosing and categorizing these granulomatous skin lesions.
Article Abstract
Background: Granulomatous dermatoses are common skin pathology, often need histopathological confirmation for diagnosis. Histologically six sub-types of granulomas found in granulomatous skin diseases- tuberculoid, sarcoidal, necrobiotic, suppurative, foreign body & histoid type. The aims of the present study were clinico-pathological evaluation of granulomatous skin lesions and their etiological classification based on histopathological examination.
Methods: It was a five years (Jan 2009- Dec 2013) retrospective study involving all the skin biopsies. Detailed clinical and histopathological features were analyzed and granulomatous skin lesions were categorized according to type of granuloma & etiology. Special stains were used in few cases for diagnostic purpose.
Results: Among 1280 skin biopsies, 186 cases (14.53%) were granulomatous skin lesions with a ratio 1:24. In histopathological sub-typing, tuberculoid granuloma was most common type (126 cases, 67.74%). Most common etiology of granuloma in the study was leprosy (107 cases, 57.52%). Other etiologies were cutaneous tuberculosis, foreign body granulomas, fungal lesions, cutaneous leishmaniasis, sarcoidosis and granuloma annulare.
Conclusion: Histopathology is established as gold standard investigation for diagnosis, categorization and clinico-pathological correlation of granulomatous skin lesions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749196 | PMC |
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