Introduction: The aim of this study was to evaluate the importance of using the entire face to assess facial profile attractiveness. The secondary objective was to assess the facial profile preferences of orthodontists, dentists and laypeople.
Methods: Two original cephalometric radiographs of two subjects (one man and one woman meeting the normality criteria) and 16 modified samples of these radiographs were used. The 18 radiographs were then converted into silhouettes and printed twice: the entire profile (A) and the lower third alone (B). The silhouettes were randomly distributed into two binders A and B. A survey was conducted using three panels of evaluators: orthodontists, dentists and laypeople. The esthetic appreciation was quantified according to the Visual Analogue Scale (VAS).
Results: Pearson's correlation coefficient was calculated to compare the scores of the entire profile with the scores of the lower third alone. The results showed that the orthodontists panel presented a much better correlation between A and B compared to dentists and especially to laypeople. A comparison of profile scores with the correlation coefficients shows that the profiles with the highest scores present the lowest correlations. The three panels of evaluators preferred the orthogonal profiles or profiles with upper lip protrusion over profiles with lower lip protrusion.
Conclusion: For profiles with values close to the norm, the lower face alone does not reveal the attractiveness of the entire facial profile. Hence, the importance of using the entire facial profile to assess the beauty of the face.
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http://dx.doi.org/10.1016/j.ortho.2015.12.007 | DOI Listing |
Front Cell Infect Microbiol
January 2025
Research Department, Sidra Medicine, Doha, Qatar.
Introduction: For years, the placenta was believed to be sterile, but recent studies reveal it hosts a unique microbiome. Despite these findings, significant questions remain about the origins of the placental microbiome and its effects on pregnancy and fetal health. Some studies suggest it may originate from the vaginal tract, while others indicate that oral bacteria can enter the maternal bloodstream and seed the placenta.
View Article and Find Full Text PDFMol Med
January 2025
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran.
Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations leads to a high rate of resistance to current therapies or reduces the efficacy of hematopoietic stem cell transplantation (HSCT), thus increasing the risk of relapse and mortality. Single-cell RNA sequencing (scRNA-seq) will enable the classification of AML and guide treatment approaches by profiling patients with different facets of the same disease, stratifying risk, and identifying new potential therapeutic targets at the time of diagnosis or after treatment.
View Article and Find Full Text PDFEnviron Res
January 2025
Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA. Electronic address:
Background: Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants that may impact placental function, and potentially gestational age acceleration (GAA), a deviation from reported and predicted gestational age. GAA potentially represents differences in cell maturation in response to a challenging environment.
Objective: This study aimed to characterize the effects of individual and mixtures of PFAS on GAA, cell composition, birth length, and birthweight.
ACS Appl Mater Interfaces
January 2025
Microfluidics Cluster UPV/EHU, BIOMICs Microfluidics Group, University of the Basque Country UPV/EHU, Vitoria-Gasteiz 01006, Spain.
Traditional cell culture methods face significant limitations in monitoring cell secretions with spatial and temporal precision. Advanced microsystems incorporating biosensors have been developed to address these challenges, but they tend to lack versatility, and their complexity, along with the requirement for specialized equipment, limits their broader adoption. CellStudio offers an innovative, user-friendly solution that exploits Printing and Vacuum Lithography combined with bead-based assays to create modular and tunable cell patterns surrounded by biosensors.
View Article and Find Full Text PDFJMIR Med Inform
January 2025
Fundación INTRAS, Valladolid, Spain.
Background: This review explores the potential of virtual reality (VR) and artificial intelligence (AI) to identify preclinical cognitive markers of Alzheimer disease (AD). By synthesizing recent studies, it aims to advance early diagnostic methods to detect AD before significant symptoms occur.
Objective: Research emphasizes the significance of early detection in AD during the preclinical phase, which does not involve cognitive impairment but nevertheless requires reliable biomarkers.
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