AI Article Synopsis
- - This study analyzes the risk factors for lymph node metastasis (LNM) in patients with superficial esophageal squamous cell carcinoma (SESCC) by examining the clinical data of 344 surgical patients from 2009 to 2013.
- - Key findings indicate that patients with tumors limited to the mucous, a diameter of less than 3 cm, and those who are highly or moderately differentiated did not have LNM, while factors like tumor diameter, invasion depth, histological type, and lymphatic involvement were significantly correlated with LNM risk.
- - The research concludes that patients with low-risk characteristics for LNM may benefit from endoscopic excision, potentially avoiding more invasive surgical procedures.
Article Abstract
Objective: To analysis the risk factors of lymph node metastasis (LNM) in superficial esophageal squamous cell carcinoma (SESCC).
Methods: The clinical data and pathological results of 344 SESCC patients, who underwent surgical treatments between January 2009 and December 2013 in West China Hospital, Sichuan University, were analyzed retrospectively. Clinicopathologic characteristics were compared between different histological types, and their possible relationships with LNM were explored by univariate and multivariate analysis.
Results: There were no LNM found in the patients with tumor limited to the mucous, tumor diameter <3 cm, highly and moderate differentiated SESCC. Univariate analysis showed that tumor diameter (P=0.004), depth of tumor invasion (P=0.009), histological type (P=0.030) and lymphatic involvement (P=0.002) were correlated with LNM. Multivariate analysis revealed that tumor diameter (P=0.007), depth of tumor invasion (P=0.003), histological type (P=0.010) and lymphatic involvement (P<0.001) were independent risk factors of LNM.
Conclusion: To the patients with low risk of LNM, such as tumor limited to the mucous, tumor diameter <3 cm, and highly and moderate differentiation, endoscopic excision may be considered as an absolute indications.
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