AI Article Synopsis
- Taurine, an amino acid found in the diet, has biological roles like regulating blood pressure and reducing inflammation.
- A study involving 14,274 women evaluated the relationship between serum taurine levels and stroke risk, comparing 241 stroke cases with 479 controls.
- Overall, no significant link was found between taurine levels and stroke risk, but an inverse association was noted in never smokers, suggesting further exploration is needed in this subgroup.
Article Abstract
Background: Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and anti-inflammation.
Methods: We conducted a prospective case-control study nested in the New York University Women's Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was measured in pre-diagnostic serum samples of 241 stroke cases and 479 matched controls.
Results: There was no statistically significant association between serum taurine and stroke risk in the overall study population. The adjusted ORs for stroke were 1.0 (reference), 0.87 (95% CI, 0.59-1.28), and 1.03 (95% CI, 0.69-1.54) in increasing tertiles of taurine (64.3-126.6, 126.7-152.9, and 153.0-308.5 nmol/mL, respectively). A significant inverse association between serum taurine and stroke risk was observed among never smokers, with an adjusted OR of 0.66 (95% CI, 0.37-1.18) and 0.50 (95% CI, 0.26-0.94) for the second and third tertile, respectively (p for trend = 0.01), but not among past or current smokers (p for interaction < 0.01).
Conclusions: We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation. Taurine, Stroke, Epidemiology, Prospective, Case-control study, NYUWHS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750934 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149348 | PLOS |
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