AI Article Synopsis
- Inflammatory bowel diseases (IBDs) like ulcerative colitis and Crohn's disease involve changes in gut microbiota, chronic inflammation due to immune responses, and issues with the gut's epithelial cells.
- Research, including genome studies and clinical trials, highlights the importance of cytokines in maintaining gut health and their role in ongoing inflammation.
- The article discusses current understanding and new ideas about cytokines in IBD, specifically in relation to immune regulation, different T cell types, and possible clinical applications.
Article Abstract
Pathogenesis of the inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) and Crohn's disease (CD), involve proinflammatory changes within the microbiota, chronic immune-mediated inflammatory responses, and epithelial dysfunction. Converging data from genome-wide association studies, mouse models of IBD, and clinical trials indicate that cytokines are key effectors of both normal homeostasis and chronic inflammation in the gut. Yet many questions remain concerning the role of specific cytokines in different IBDs within distinct regions of the gut, and regarding cellular mechanisms of action. In this article, we review current and emerging concepts concerning the role of cytokines in IBD with a focus on immune regulation, T cell subsets, and potential clinical applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838490 | PMC |
| http://dx.doi.org/10.1097/MIB.0000000000000714 | DOI Listing |
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