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http://dx.doi.org/10.4103/0971-6580.172259 | DOI Listing |
Int J Nanomedicine
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia.
Introduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. Thus, this study aimed to develop a rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) to improve solubility and bioavailability.
Methods: The RL-SNEDDS was prepared by aqueous titration method with eucalyptus oil (oil phase), tween 80 (surfactant), and PEG 400 (co-surfactant) and optimization was performed by 3 factorial design.
Cell Mol Biol (Noisy-le-grand)
January 2025
Laboratory of Cellular Toxicology, Faculty of Science, Department of Biology, Badji Mokhtar University, Annaba, Algeria.
Introduction: Turpentine derivatives and Eucalyptus oil are herbal substances traditionally used to treat various skin infections. Limited non-clinical data suggest they exert an immunological activity, but only scant information exists on their antibiotic effects. This in vitro study has been carried out to investigate the antibacterial and antifungal activity of a marketed skin ointment, its active pharmaceutical ingredients larch turpentine, eucalyptus oil, and turpentine oil, and their mixture, against bacteria and yeasts commonly present on the skin and causing skin infections.
View Article and Find Full Text PDFGeorgian Med News
October 2024
1G. Eliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi, Georgia.
The emergence of antibiotic-resistant pathogens necessitates alternative therapies for treating microbial infections, especially in the oral cavity and upper respiratory tract. Our team has developed Phage Pastilles, a controlled-release formulation containing bacteriophages that target common pathogens, including Streptococcus pyogenes, Streptococcus salivarius, Staphylococcus aureus, Enterococcus faecalis, and E. coli.
View Article and Find Full Text PDFInt J Food Microbiol
February 2025
Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:
Photodynamic inactivation, as a safe and effective antimicrobial technology that does not damage the organoleptic properties of the food itself, decreases the use of preservatives and is gradually gaining attention in the food industry. This study selected octyl gallate (OG) as an antimicrobial photosensitizer with eucalyptus oil as the oil phase and prepared it as an octyl gallate nanoemulsion (OG-NE) to ensure the delivery of the photosensitizer. Escherichia coli and Staphylococcus aureus inactivation with the OG-NE combined with photodynamic technology, as well as the effect on the quality of food products, was investigated.
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