Effect of lanosterol on human cataract nucleus.

Aim: To study the effect of lanosterol on age-related cataractous human lens nuclei.

Materials And Methods: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity.

Results: Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days.

Conclusion: Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.