AI Article Synopsis
- The study aimed to assess how maternal demographics and abnormal first-trimester ultrasound markers impact the risk of congenital anomalies (CAs) in newborns, specifically when initial scans show a structurally normal fetus.
- Conducted with high-risk pregnant women, the research involved detailed ultrasounds between 11-14 weeks and applied multilevel regression analysis to identify correlations between maternal factors, abnormal markers, and CAs at birth.
- Findings revealed that abnormal ultrasound indicators, like increased nuchal translucency, significantly raised the odds of congenital anomalies, highlighting a notable risk especially for conditions like trisomies 21, 18, and 13.
Article Abstract
Objective: The objective of this study was to analyze the influence of maternal demographic characteristics and abnormal first-trimester sonographic markers on congenital anomalies (CAs) at birth when the fetus is structurally normal at the 11- to 14-week ultrasound.
Methods: This prospective cohort study comprised high-risk women undergoing routine antenatal care. Detailed assessments of fetal anatomy and first-trimester sonographic markers were performed at 11-14 weeks of pregnancy. Multilevel regression analysis was used to determine the effects of maternal characteristics and abnormal first-trimester sonographic markers on the incidence of CA at birth.
Results: Three hundred and ten patients were evaluated, and 41 patients (13.2%) had an anomalous newborn. The presence of a specific indication at the first-trimester ultrasound (OR: 2.72; CI 95% 1.09-6.74) or a nuchal translucency (NT) thickness greater than 2.5 mm increased the risk of CA at birth by three fold (OR: 3.10; CI 95% 1.07-9.59). High adjusted risks for trisomies 21, 18 and 13 increased the likelihood of having a structurally abnormal newborn by five, twelve and six fold, respectively.
Conclusion: Increased NT and/or high adjusted risks for trisomies 21, 18, and 13 increase the risk of CA at birth, even in fetuses with a structurally normal 11- to 14-week ultrasound scan.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/14767058.2016.1152246 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!