AI Article Synopsis
- Obesity may seem protective against osteoporosis based on cross-sectional studies, but a longitudinal study reveals that it is linked to increased bone loss over time in older adults.
- The study analyzed changes in bone mineral density (BMD) over 10 years in a diverse sample of older adults, finding that obese individuals experienced a greater annual loss in femoral neck BMD compared to those with normal weight.
- The results emphasize the need to consider long-term impacts of obesity on bone health, suggesting that carrying excess weight may not actually safeguard against bone density loss as previously thought.
Article Abstract
Unlabelled: Obesity appears protective against osteoporosis in cross-sectional studies. However, results from this longitudinal study found that obesity was associated with bone loss over time. Findings underscore the importance of looking at the longitudinal relationship, particularly given the increasing prevalence and duration of obesity among older adults.
Introduction: Cross-sectional studies have found a positive association between body mass index (BMI) and bone mineral density (BMD), but little is known about the longitudinal relationship in US older adults.
Methods: We examined average annual rate of change in BMD by baseline BMI in the Health, Aging, and Body Composition Study. Repeated measurement of BMD was performed with dual-energy X-ray absorptiometry (DXA) at baseline and years 3, 5, 6, 8, and 10. Multivariate generalized estimating equations were used to predict mean BMD (femoral neck, total hip, and whole body) by baseline BMI (excluding underweight), adjusting for covariates.
Results: In the sample (n = 2570), 43 % were overweight and 24 % were obese with a mean baseline femoral neck BMD of 0.743 g/cm(2), hip BMD of 0.888 g/cm(2), and whole-body BMD of 1.09 g/cm(2). Change in total hip or whole-body BMD over time did not vary by BMI groups. However, obese older adults lost 0.003 g/cm(2) of femoral neck BMD per year more compared with normal weight older adults (p < 0.001). Femoral neck BMD change over time did not differ between the overweight and normal weight BMI groups (p = 0.74). In year 10, adjusted femoral neck BMD ranged from 0.696 g/cm(2) among obese, 0.709 g/cm(2) among normal weight, and 0.719 g/cm(2) among overweight older adults.
Conclusions: Findings underscore the importance of looking at the longitudinal relationship between body composition and bone mineral density among older adults, indicating that high body mass may not be protective for bone loss over time.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892439 | PMC |
| http://dx.doi.org/10.1007/s00198-016-3506-x | DOI Listing |
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