AI Article Synopsis
- Telocytes (TCs) are specialized interstitial cells characterized by their long extensions called telopodes, identified through specific immune markers.
- They have been discovered in various mammalian organs, including the trachea and lungs, although their exact functions are still not fully understood.
- Recent studies highlight the unique gene and protein profiles of TCs, suggesting they could play a significant role in the development of lung diseases.
Article Abstract
Telocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps), as shown by immune-positive staining against CD34, c-kit and vimentin. They were found in many organs of mammals, with potential biological functions, including the trachea and lung, even though the exact function remains unclear. Here, we give a historical overview of the TCs research field and summarize the latest findings associated with TCs, with a special focus on the recent progress about TCs specific gene and protein profiles that has been made in understanding that TCs may play a potential, but important, role in the pathogenesis of lung diseases.
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| http://dx.doi.org/10.1016/j.semcdb.2016.02.008 | DOI Listing |
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