AI Article Synopsis
- A genome-wide association study was conducted on 1130 premenopausal women to identify genetic variants linked to three iron-related traits in the blood.
- The strongest association was found between total iron binding capacity and genetic variants near the TF gene, with significant links to the HFE gene, which is related to hemochromatosis.
- While there were no strong associations with serum iron levels, a suggestive link to variants in HFE was noted, supporting previous research findings in older populations.
Article Abstract
A genome-wide association study was performed on 1130 premenopausal women to detect common variants associated with three serum iron-related phenotypes. Total iron binding capacity was strongly associated (p=10(-14)) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p=4×10(-7)), which encodes the human hemochromatosis gene. Association was also detected between percent iron saturation (p=10(-8)) and variants in the chromosome 6 region containing both HFE and SLC17A2, which encodes a phosphate transport protein. No significant associations were detected with serum iron, but variants in HFE were suggestive (p=10(-6)). Our results corroborate prior studies in older subjects and demonstrate that the association of these genetic variants with iron phenotypes can be detected in premenopausal women.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746500 | PMC |
| http://dx.doi.org/10.1016/j.bcmd.2015.12.002 | DOI Listing |
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