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Loss of increases type I interferon signalling and reduces pancreatic tumour growth by enhancing immune cell infiltration.
Front Immunol
January 2025
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer, and despite low incidence rates, it remains the sixth leading cause of cancer related deaths worldwide. Immunotherapy, which aims to enhance the immune system's ability to recognize and eliminate cancer cells, has emerged as a promising approach in the battle against PDAC. PARP7, a mono-ADP-ribosyltransferase, is a negative regulator of the type I interferon (IFN-I) pathway and has been reported to reduce anti-tumour immunity.
View Article and Find Full Text PDFPlasma Lipid Profile Among Perimenopausal Latvian Women in Relation to Dietary Habits.
Nutrients
January 2025
Faculty of Agriculture and Food Technology, Latvia University of Life Sciences and Technologies, LV-3001 Jelgava, Latvia.
Hormonal changes throughout a woman's life cycle significantly affect serum lipid levels. Alterations in the serum lipid profile can increase the risk of cardiovascular diseases (CVDs). Additionally, nutrition and dietary habits are crucial for managing dyslipidemia.
View Article and Find Full Text PDFOccurrence levels of perfluoroalkyl carboxylic acids (PFCA) and perfluoroalkyl sulfonic acids (PFSA) in European perch (Perca fluviatilis) samples collected from inland waters in Latvia: Component profiles, spatial distribution and dietary exposure to consumers.
Environ Res
January 2025
Institute of Food Safety, Animal Health and Environment "BIOR", Lejupes iela 3, Riga, LV-1076, Latvia.
This study was performed to evaluate the occurrence of perfluorinated substances (PFAS) in European perch (Perca fluviatilis) samples from Latvian freshwater bodies. Twenty-nine samples of perch tissue homogenates were analyzed on the content of PFAS representing different sampling sites to cover all territory of Latvia evenly. The total PFAS concentrations (∑) ranged from 0.
View Article and Find Full Text PDFAcidification level variability in hemiboreal production forest drained peatland catchments and after different intensity regeneration fellings using critical loads modelling approach.
J Environ Manage
February 2025
University of Latvia, The Faculty of Science and Technology, Jelgava Street 1, LV-1004 Riga, Latvia.
Forestry activities, i.e., drainage system maintenance or regeneration fellings may alter the water quality in catchments as well as in runoff and induce risks of acidification.
View Article and Find Full Text PDFSurvival of Eurasian lynx in the human-dominated landscape of Europe.
Conserv Biol
January 2025
Chair of Wildlife Ecology and Management, Albert Ludwigs University of Freiburg, Freiburg, Germany.
Survival and cause-specific mortality rates are vital for evidence-based population forecasting and conservation, particularly for large carnivores, whose populations are often vulnerable to human-caused mortalities. It is therefore important to know the relationship between anthropogenic and natural mortality causes to evaluate whether they are additive or compensatory. Further, the relation between survival and environmental covariates could reveal whether specific landscape characteristics influence demographic performance.
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