Background: Distinguishing between diffuse subacute alopecia areata (AA), in which the peribulbar infiltrate is absent, and pattern hair loss is challenging, particularly in cases that lack marked follicular miniaturization and a marked catagen/telogen shift.
Objective: We sought to distinguish diffuse AA from pattern hair loss using CD3(+) T lymphocytes.
Methods: A total of 28 cases of subacute AA and 31 cases of pattern hair loss were selected and a 4-mm punch biopsy was performed. All the specimens were processed using the "HoVert" (horizontal and vertical) technique. In all cases, hematoxylin-eosin and immunohistochemical stains for CD3, CD4, CD8, and CD20 were performed.
Results: The presence of CD3(+) lymphocytes within empty follicular fibrous tracts (stela), even without a concomitant peribulbar infiltrate, is a reliable histopathological clue in supporting a diagnosis of AA (sensitivity 0.964, specificity 1, P ≤ .001).
Limitations: Limited tissue for analysis remained in the clinical sample tissue blocks.
Conclusion: The presence of CD3(+) T-cells within empty follicular fibrous tracts (stela) supports a diagnosis of AA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jaad.2015.12.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits.
BMC Genomics
January 2025
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Background: Rex rabbit is famous for its silky and soft fur coat, a characteristic predominantly attributed to its hair follicles. Numerous studies have confirmed the crucial roles of mRNAs and non-coding RNAs (ncRNAs) in regulating key cellular processes such as cell proliferation, differentiation, apoptosis and immunity. However, their involvement in the regulation of the hair cycle in Rex rabbits remains unknown.
View Article and Find Full Text PDFCombination of oral minoxidil and bicalutamide for the treatment of female pattern hair loss in adolescents.
J Am Acad Dermatol
January 2025
Sinclair Dermatology, 2 Wellington Parade, East Melbourne, VIC 3108.
Adsorption and Bulk Assembly of Quaternized Hydroxyethylcellulose-Anionic Surfactant Complexes on Negatively Charged Substrates.
Polymers (Basel)
January 2025
Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria, Plaza de la Ciencias s/n, 28040 Madrid, Spain.
This study examines the adsorption and bulk assembly behaviour of quaternized hydroxyethylcellulose ethoxylate (QHECE)-sodium dodecyl sulphate (SDS) complexes on negatively charged substrates. Due to its quaternized structure, QHECE, which is used in several industries, including cosmetics, exhibits enhanced electrostatic interactions. The phase behaviour and adsorption mechanisms of QHECE-SDS complexes are investigated using model substrates that mimic the wettability and surface charge of damaged hair fibres.
View Article and Find Full Text PDFA Lateral Line Specific Mucin Involved in Cupula Growth and Vibration Detection in Zebrafish.
Int J Mol Sci
January 2025
Institute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai 201306, China.
The lateral line system in fish is crucial for detecting water flow, which facilitates various behaviors such as prey detection, predator avoidance, and rheotaxis. The cupula, a gelatinous structure overlaying the hair cells in neuromasts, plays a key role in transmitting mechanical stimuli to hair cells. However, the molecular composition of the cupula matrix remains poorly understood.
View Article and Find Full Text PDFTrichoscopic Analysis of Healthy Indian Males for Standardization of the Measurable Parameters: An Observational, Cross-sectional Study.
Indian Dermatol Online J
December 2024
The Venkat Centre for Advanced Dermatology, Plastic Surgery and ENT, Bengaluru, Karnataka, India.
Background: Trichoscopy is a simple, noninvasive tool to help in the diagnosis of various hair and scalp disorders. There is paucity of data on the normal trichoscopic parameters of hair density and diameter in the Indian population.
Aim: The aim of this study was to establish the trichoscopic patterns of hair and scalp in healthy Indian males and to provide a framework for future reference.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!