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Non-pharmacological Radical Methods for Treating Postpartum Depression Around the Globe: A Narrative Review.
Cureus
December 2024
Preventive Medicine, Sree Balaji Medical College and Hospital, Chennai, IND.
Mental health conditions during pregnancy, especially postpartum depression (PPD), can have profound and long-lasting effects on the individual, impeding her ability to bond with her child and disrupting the family dynamics. Although pharmacological treatments like antidepressants are the mainstay treatment options, several mothers have concerns about their safety and potential side effects, especially breastfeeding mothers. There is an emerging interest in exploring the use of non-pharmacological interventions as an alternative treatment modality for PPD.
View Article and Find Full Text PDFObjectives: Should a young person receive psychotherapy or medication for their depression and on what evidence do we base this decision? In this paper, we test the factors across modalities that may influence comparability between medication and psychotherapy trials.
Methods: We included 92 randomised controlled trials (RCTs) of psychotherapy and medication for child and adolescent depression (mean age 4-18 years). Using meta-analyses, we compared (a) participant characteristics and (b) trial characteristics in medication and psychotherapy trials.
Catalyst for change: Psilocybin's antidepressant mechanisms-A systematic review.
J Psychopharmacol
January 2025
Division of Clinical Psychological Intervention, Freie Universität Berlin, Berlin, Germany.
Background: Recent clinical trials suggest promising antidepressant effects of psilocybin, despite methodological challenges. While various studies have investigated distinct mechanisms and proposed theoretical opinions, a comprehensive understanding of psilocybin's neurobiological and psychological antidepressant mechanisms is lacking.
Aims: Systematically review potential antidepressant neurobiological and psychological mechanisms of psilocybin.
Effects of Centrally Acting Analgesics on Resting-State Electroencephalography Biomarker Candidates of Chronic Pain.
J Pain
January 2025
Technical University of Munich (TUM), School of Medicine and Health, Department of Neurology, Munich, Germany; TUM, School of Medicine and Health, TUM-Neuroimaging Center, Munich, Germany; TUM, School of Medicine and Health, Center for Interdisciplinary Pain Medicine, Munich, Germany. Electronic address:
Resting-state electroencephalography (rsEEG) holds promise as a biomarker of chronic pain. However, the impact of centrally acting analgesics like opioids, antiepileptics, and antidepressants on rsEEG remains unclear. This confounds and limits the interpretability of previous studies and questions the specificity of some rsEEG biomarker candidates of chronic pain, especially for potential diagnostic biomarkers.
View Article and Find Full Text PDFPediatric Attention-Deficit/Hypearativity Disorder and Disruptive Mood Dysregulation Disorder: Analyzing National Treatment Trends.
J Pediatr
January 2025
Department of Psychiatry and Behavioral Health, Pennsylvania State College of Medicine, Hershey, PA.
Objective: This study investigated how a disruptive mood dysregulation disorder (DMDD) diagnosis infleunces treatment selection and sequencing in children with attention-deficit/hyperactivity disorder (ADHD).
Study Design: This multicenter, population-based, retrospective cohort study analyzed data from TriNetX Research Network (June 2013 through July 2024). Youth with ADHD (without DMDD) formed the control cohort (n=631,295).
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