AI Article Synopsis
- Cannabis use among adolescents is rising, and both cannabis and traumatic brain injury (TBI) are linked to an increased risk of psychosis, especially in developing brains.
- Two adolescent cases are discussed where patients with a history of TBI and heavy cannabis use developed psychotic symptoms, highlighting the potential dangers of this combination.
- The evidence suggests that cannabis may act as a neurological stressor, increasing the risk of psychosis rather than serving as a beneficial treatment, especially for young individuals with a TBI.
Article Abstract
Background: Both cannabis and traumatic brain injury (TBI) pose risks on the developing brain, including a potential increased vulnerability for developing psychosis. Recent reports detail an upward trend in both adolescent cannabis use and the concentration of THC, the most potent psychoactive component in cannabis. Similarly, it is estimated that 1.7 million Americans incur a TBI each year. Previously trivialized as a minor nuisance, attitudes towards TBIs are changing as researchers and the public recognize TBIs' possible long-lasting sequelae.
Case Report: Two cases are presented of adolescent patients with histories of TBI and self-reported heavy, recreational cannabis use who developed symptoms of psychosis.
Discussion: Similar neuronal signaling pathways involved in cannabis ingestion and TBI recovery, specifically CB1 receptors of the endocannabinoid system, as well as the allostatic load model provide context for the two presented cases. Given the cases and theories presented, we believe that cannabis use may act as a neurological stressor and risk factor for psychosis outweighing its possible benefits as a therapeutic solution for pain in late adolescent and young adult populations.
Significance: The presented cases provide further support for the compounded risk of developing psychosis following TBI and cannabis use.
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| http://dx.doi.org/10.1111/ajad.12338 | DOI Listing |
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