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http://dx.doi.org/10.1038/nbt.3474 | DOI Listing |
Angew Chem Int Ed Engl
December 2024
Ecole Normale Supérieure, Department of Chemistry, 24, rue Lhomond, 75005, Paris, FRANCE.
Giant unilamellar vesicles (GUVs) are widely used minimal cell models where essential biological features can be reproduced, isolated and studied. Although precise spatio-temporal distribution of membrane domains is a process of crucial importance in living cells, it is still highly challenging to generate anisotropic GUVs with domains at user-defined positions. Here we describe a novel and robust method to control the spatial position of lipid domains of liquid-ordered (Lo) / liquid-disordered (Ld) phase in giant unilamellar vesicles (GUVs).
View Article and Find Full Text PDFMacromol Rapid Commun
December 2024
Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center, Jieyang, 515200, P. R. China.
Photothermal-triggering shape memory polyurethane allows for precise and controllable shape transformation under remote light stimulation, making it highly desirable for applications in intelligent devices. This study develops a sustainable and high-performance lignin-based polyurethane (LPU) using a one-stone-two-birds strategy, wherein lignin serves as both a synthetic monomer and an internal photothermal agent. The incorporation of lignin significantly improved the mechanical properties of LPU, achieving a tensile strength of 42.
View Article and Find Full Text PDFFront Nutr
December 2024
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Introduction: Hypertension (HTN) is a prevalent condition associated with numerous cardiovascular and non-cardiac complications. Lifestyle interventions, including dietary adjustments, offer promising avenues for hypertension management. However, the precise relationship between dietary antioxidants and hypertension risk necessitates further investigation.
View Article and Find Full Text PDFACS Omega
December 2024
Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, Bornova, Izmir 35040, Turkey.
This study encompasses the validation of a simple, rapid, and sensitive HPLC/UV method developed in accordance with the guidelines set by ICH Q2(R2) for obtaining the active pharmaceutical ingredient from the glycosaminoglycan family in topical formulations. Previous methods reported for analyzing glycosaminoglycans in semisolid formulations are relatively complex and time-consuming, involving extraction, purification, and derivatization. This developed analytical method allows for straightforward extraction of the active pharmaceutical ingredient from the matrix, enabling the direct injection of samples.
View Article and Find Full Text PDFPharmacogenomics is central to precision medicine, informing medication safety and efficacy. Pharmacogenomic diplotyping of complex genes requires full-length DNA sequences and detection of structural rearrangements. We introduce StarPhase, a tool that leverages PacBio HiFi sequence data to diplotype 21 CPIC Level A pharmacogenes and provides detailed haplotypes and supporting visualizations for HLA-A, HLA-B, and CYP2D6.
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