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Role of Vibrio cholerae exochitinase ChiA2 in horizontal gene transfer. | LitMetric

Role of Vibrio cholerae exochitinase ChiA2 in horizontal gene transfer.

Can J Microbiol

Division of Biochemistry, National Institute of Cholera and Enteric Diseases, P33 C.I.T. Road, Scheme XM, Beliaghata, Kolkata-700010, India.

Published: March 2016

AI Article Synopsis

Article Abstract

Vibrio cholerae exochitinase ChiA2 plays a key role in acquisition of nutrients by chitin hydrolysis in the natural environment as well as in pathogenesis in the intestinal milieu. In this study we demonstrate the importance of ChiA2 in horizontal gene transfer in the natural environment. We found that the expression of ChiA2 and TfoX, the central regulator of V. cholerae horizontal gene transfer, varied with changes in environmental conditions. The activity of ChiA2 was also dependent on these conditions. In 3 different environmental conditions tested here, we observed that the supporting environmental condition for maximum expression and activity of ChiA2 was 20 °C, pH 5.5, and 100 mmol/L salinity in the presence of chitin. The same condition also induced TfoX expression and was favorable for horizontal gene transfer in V. cholerae. High-performance liquid chromatography analysis showed that ChiA2 released a significant amount of (GlcNAc)2 from chitin hydrolysis under the favorable condition. We hypothesized that under the favorable environmental condition, ChiA2 was upregulated and maximally active to produce a significant amount of (GlcNAc)2 from chitin. The same environmental condition also induced tfoX expression, followed by its translational activation by the (GlcNAc)2 produced, leading to efficient horizontal gene transfer.

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Source
http://dx.doi.org/10.1139/cjm-2015-0556DOI Listing

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