AI Article Synopsis
- Hepatocellular carcinoma (HCC) is often diagnosed at advanced stages, making it unsuitable for surgery or transplantation, and existing systemic therapies have limited effectiveness.
- While HCC can respond to radiation, conventional external-beam treatments are restricted due to the sensitivity of surrounding healthy liver and nearby organs.
- Selective internal radiation therapy (SIRT) using Yttrium-90 microspheres has shown modest success in treating unresectable HCC, as demonstrated by a case of a patient with a large, multifocal tumor who experienced a significant response to SIRT.
Article Abstract
Hepatocellular carcinoma (HCC) is predominantly diagnosed in advanced stages and not amenable to surgical resection and transplantation. Systemic therapies have had a limited efficacy in treating HCC. Although HCC is a radiosensitive tumor, treatments with external-beam radiation are limited by radiosensitivity of normal liver tissue and surrounding organs-at-risk, i.e. bowel, stomach, and kidney. Several large retrospective series have demonstrated a modest effect of selective internal radiation therapy (SIRT) with Yttrium-90 ((90)Y) microspheres in unresectable HCC, both in terms of tumor response and survival. The authors present a patient with an extremely large, multifocal, unresectable HCC who achieved a dramatic response with SIRT treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727862 | PMC |
| http://dx.doi.org/10.7759/cureus.425 | DOI Listing |
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