Importance: Radiation-induced angiosarcoma after conservative treatment of breast cancer affects a small percentage of patients but has a significant impact on survival. Early detection requires a high index of suspicion and is important for optimal management of this aggressive disease.
Observations: The patient reported here presented with radiation-induced angiosarcoma of the left breast 14 years after radiation therapy. Histopathology was positive for anti-CD31, anti-CD34, D2-40, and anti-factor VIII (von Willebrand). She underwent a total mastectomy and is still in remission 20 months later. The authors present a review of the clinical presentation, diagnostic methods, and treatment options.
Conclusions: This case report demonstrates the importance of long-term follow-up and investigation of even the subtlest cutaneous changes in the breast after radiation treatment, because radiation-induced angiosarcoma is a very aggressive disease that could benefit from early diagnosis and management.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/1203475416631525 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Case of Radiation-Induced Angiosarcoma after Breast-Conserving Surgery with Hypofractionated Radiotherapy in a Japanese Patient.
Acta Med Okayama
December 2024
Department of Radiology, Kawasaki Medical School.
Radiation-induced angiosarcoma (RIAS) is a rare, late adverse event of radiotherapy comprising approximately half of all radiation-induced sarcomas. It has a relatively short latency period and generally unfavorable prognosis. This study presents a case of RIAS that developed 5 years and 11 months after the completion of hypofractionated radiotherapy (42.
View Article and Find Full Text PDFArticle Synopsis
- The development of lichen planus (LP) from radiation is very rare, with only 14 cases noted, and malignancy linked to LP is uncommon, primarily seen in oral forms.
- This report discusses a unique case of erosive cutaneous LP that transformed into malignancy at a site previously treated with radiation, highlighting the need for careful evaluation and monitoring in similar cases.
Post-radiation Angiosarcoma of the Vagina: A Case Report and Literature Review.
Cureus
October 2024
Radiology, Radiology Associates of North Texas, Fort Worth, USA.
Article Synopsis
- * A unique case was reported of an 83-year-old woman who developed vaginal angiosarcoma 14 years after radiation treatment for rectal cancer.
- * The patient underwent Taxol chemotherapy and had an impressive response, achieving complete remission four years after the treatment.
Prognosis of primary cutaneous angiosarcoma versus radiation-induced angiosarcoma: A cohort study.
J Eur Acad Dermatol Venereol
November 2024
Quality Conferences Office at the Clinical State Registry Baden-Württemberg GmbH of the Baden-Württemberg Cancer Registry, Stuttgart, Germany.
Neoadjuvant chemotherapy for radiation associated angiosarcoma (RAAS) of the breast: A retrospective single center study.
Breast
December 2024
Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), Department of Surgical Oncology, Plesmanlaan 121, Amsterdam, the Netherlands. Electronic address:
Background: Radiation associated angiosarcoma (RAAS) of the breast is a rare malignancy with poor survival. Optimal treatment strategies remain uncertain due to a lack of data, and vary between surgery alone and a combination of surgery with (neo)adjuvant chemotherapy (NACT) and/or re-irradiation. The aim of this study was to evaluate the potential benefit of taxane based NACT.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!