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Drug repositioning of mesalamine via supramolecular nanoassembly for the treatment of drug-induced acute liver failure.
Theranostics
January 2025
Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Acute liver failure (ALF) is characterized by rapid hepatic dysfunction, primarily caused by drug-induced hepatotoxicity. Due to the lack of satisfactory treatment options, ALF remains a fatal clinical disease, representing a grand challenge in global health. For the drug repositioning to ALF of mesalamine, which is clinically approved for the treatment of inflammatory bowel disease (IBD), we propose a supramolecular prodrug nanoassembly (SPNs).
View Article and Find Full Text PDFTornado sheltering: Challenges and solutions including public storm shelters.
J Emerg Manag
January 2024
Department of Geosciences, Mississippi State University, Mississippi State, Mississippi.
Tornadoes are a considerable threat across the United States, occurring in many regions of the country on a frequent basis throughout the year. Finding a safe place to go during a tornado can be a challenge for many individuals, and, in some situations, there is no safe place available. Increasing the number of tornado shelters and establishing them in regions where they are not currently present can greatly improve the safety of local residents and visitors, especially for those who are unable to afford retrofitting a shelter into their own home or business.
View Article and Find Full Text PDFTargeted delivery of cytotoxic proteins lipid-based nanoparticles to primary Langerhans cells.
Nanoscale
January 2025
Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Targeted delivery has emerged as a critical strategy in the development of novel therapeutics. The advancement of nanomedicine hinges on the safe and precise cell-specific delivery of protein-based therapeutics to the immune system. However, major challenges remain, such as developing an efficient delivery system, ensuring specificity, minimizing off-target effects, and attaining effective intracellular localization.
View Article and Find Full Text PDFDelivering safe, person-centred care for acutely unwell older people on virtual wards.
Nurs Older People
January 2025
Doccla UK Ltd, London, England.
A virtual ward can provide hospital-level care for older people in their usual place of residence during an episode of acute illness. Care on a virtual ward may be delivered through a mix of in-person home visits, telephone or video calls and remote monitoring. This model of care can prevent unnecessary inpatient admissions, which in turn can prevent the development of associated complications in this patient population, such as deconditioning, delirium and hospital-acquired infections.
View Article and Find Full Text PDFAnaesthetic management of oncological disease in pregnancy: a narrative review.
Anaesthesia
January 2025
Department of Anaesthesia, University Hospital of Wales, Cardiff, UK.
Introduction: Cancer complicates approximately 1 in 2000 pregnancies, with increasing incidence due to factors such as increased maternal age, obesity and advancements in antenatal testing. Anaesthetists play a crucial role in managing pregnant patients with cancer, both during delivery and in providing anaesthesia for oncological treatments. This review explores the challenges in anaesthetic management and specific considerations for common cancers encountered in pregnant patients.
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