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Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins.
Elife
September 2024
Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany.
The Sonic hedgehog (Shh) signaling pathway controls embryonic development and tissue homeostasis after birth. This requires regulated solubilization of dual-lipidated, firmly plasma membrane-associated Shh precursors from producing cells. Although it is firmly established that the resistance-nodulation-division transporter Dispatched (Disp) drives this process, it is less clear how lipidated Shh solubilization from the plasma membrane is achieved.
View Article and Find Full Text PDFHigh-density lipoprotein infusion therapy: A review.
J Clin Lipidol
June 2024
Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA (Drs Foldyna and Ghoshhajra).
Increased cholesterol-rich, low-density, non-calcified atheromas as assessed by computer coronary tomography angiography analyses have been shown to predict myocardial infarction significantly better than coronary artery calcium score or the presence of obstructive coronary artery disease (CAD) as evaluated with standard coronary angiography. Low serum high-density lipoprotein (HDL) cholesterol values are an independent risk factor for CAD. Very small, lipid-poor preβ-1 HDL particles have been shown to be most effective in promoting cellular cholesterol efflux.
View Article and Find Full Text PDFSchisandrin A in Upregulates the LDL Receptor by Inhibiting PCSK9 Protein Stabilization in Steatotic Model.
J Microbiol Biotechnol
February 2024
Department of Food and Nutrition, Gangseo University, Seoul 07661, Republic of Korea.
extract (SCE) protects against hypocholesterolemia by inhibiting proprotein convertase subtilisin/kexin 9 (PCSK9) protein stabilization. We hypothesized that the hypocholesterolemic activity of SCE can be attributable to upregulation of the PCSK9 inhibition-associated low-density lipoprotein receptor (LDLR). Male mice were fed a low-fat diet or a Western diet (WD) containing SCE at 1% for 12 weeks.
View Article and Find Full Text PDFIn vitro binding analysis of legacy-linear and new generation-cyclic perfluoro-alkyl substances on sex hormone binding globulin and albumin, suggests low impact on serum hormone kinetics of testosterone.
Toxicology
December 2023
Deparment of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy.
In humans, serum testosterone (T) is largely bound to the sex hormone binding globulin (SHBG) and human serum albumin (hSA), resulting in a 2-3 % of unbound or "free" active quote (FT). Endocrine-disrupting chemicals, including perfluoro-alkyl substances (PFAS), are recognized to interfere with the hormonal axes, but the possible impact on the FT quote has not been addressed so far. Here we investigated the possible competition of two acknowledged PFAS molecules on T binding to SHBG and hSA.
View Article and Find Full Text PDFLipid availability during in vitro maturation alters oocyte lipid content and blastocyst development and metabolism.
Reprod Domest Anim
July 2023
Laboratory of Embryonic Metabolism and Epigenetics, Center of Natural and Human Science, Federal University of ABC, Santo André, Brazil.
Lipids play a crucial role in various biological functions, including membrane composition, energy storage, cell signalling, and metabolic and epigenetic processes. Abnormal lipid accumulation and metabolism during in vitro maturation (IVM) of oocytes have been linked to the use of fetal bovine serum (FBS), even though it provides several beneficial molecules, contributing to the oocyte competence. Delipidating agents have been used to mitigate these deleterious effects, but they can have adverse effects on embryonic development.
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