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Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems? | LitMetric

Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?

Biochim Biophys Acta

CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France.

Published: April 2016

AI Article Synopsis

Article Abstract

By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbcan.2016.01.005DOI Listing

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