Colorectal cancer is a generally slow-growing cancer that is highly curable when detected at an early, localized stage. Dueto the lack of symptoms, even with advanced disease, screening is required to ensure cancers are detected early. Currently,however, only 3 in 5 people eligible for CRC screening undergo screening. Barriers vary somewhat by screening test and may differ in individual patients. Screening tests are generally more affordable due to recent changes in Medicare and private insurance coverage. Discussion with patients to identify barriers to screening makes it possible to select among the currently available invasive and noninvasive screening tests to determine the test that best meets the patient’s health needs with the overall goal of increasing screening for a preventable disease.
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Claudins as diagnostic tools and therapeutic targets-Glimpse of the horizon.
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Claudins (CLDNs) play a crucial and indispensable role as fundamental components within the structure of tight junctions. Due to the distinct and unique distribution pattern exhibited by CLDNs in both normal and malignant tissues, these proteins have garnered significant attention as pivotal targets for systemic anti-cancer therapy and as noteworthy diagnostic markers. This review provides a comprehensive and detailed elucidation of the fundamental understanding surrounding CLDNs, their intricate expression patterns, the potential role they play in cancer diagnosis and therapeutic potentials; all encapsulated within a succinct summary of the cutting-edge advancements and the information derived from various clinical trials.
View Article and Find Full Text PDFDiagnostic clues in herpes encephalitis following radiation therapy.
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The Gaffin Center for Neuro-Oncology, Sharett Institute of Oncology, Hadassah Medical Center, and Faculty of Medicine, The Hebrew University of Jerusalem, Israel. Electronic address:
Introduction: Herpes encephalitis is known to affect patients undergoing brain radiotherapy, but early diagnosis and treatment, the foremost determinants of disease outcome, remain challenging in this patient population. This can be due to attribution of symptoms to the brain tumor and radiation side effects, as well as patients' atypical clinical presentation. Here we sought to highlight pearls and pitfalls in the clinical course and diagnostic workup which may facilitate timely diagnosis and improve disease outcome.
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Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address:
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Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
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Biologic Therapy Is Associated With Improved Oncologic Outcomes in Crohn's Disease-Associated Colorectal Cancer.
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Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Ohio.
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