Carbonyl compounds bearing a γ-amino group are valuable pharmacologically active targets. Regioselective γ-C-N bond formation is achieved with simple enone substrates through controlled dienolate reactivity toward azodicarboxylate electrophiles. The amination reaction occurs readily with sterically demanding nucleophiles and is stereoselective.
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| http://dx.doi.org/10.1021/acs.orglett.5b03689 | DOI Listing |
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