Background: Placebo effects emerging from expectancies of relatives, also known as placebo by proxy, is a rather unexplored field. In this study, we assume a correlation between parental anxiety/expectancy and postoperative morbidities in children. Accordingly, a reduction of parental anxiety is expected to enhance the effect of treatment.
Methods: From October 2012 to June 2013, parents of 282 children completed a self-report closed-ended questionnaire embedded in a main RCT at three ambulatory care centers.
Results: There were no significant associations between parental expectancy or anxiety and children experiencing vomiting and pain.
Conclusion: The present study is the first to investigate placebo by proxy in acupuncture treatment for children. The findings were not able to demonstrate any placebo effect by proxy. Unknown confounders and limitations of methods may have contributed to the negative findings. Thus, the findings must be read with precaution, as the possibility of a type II error cannot be excluded.
Trial Registration: ClinicalTrials.gov NCT01729052.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000442565 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Accounting for local incidence when estimating rotavirus vaccine efficacy among countries: a pooled analysis of monovalent rotavirus vaccine trials.
Am J Epidemiol
December 2024
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Rotavirus vaccine appears to perform sub-optimally in countries with higher rotavirus burden. We hypothesized that differences in the magnitude of rotavirus exposures may bias vaccine efficacy (VE) estimates, so true differences in country-specific rotavirus VE would be exaggerated without accommodating differences in exposure. We estimated VE against any-severity and severe rotavirus gastroenteritis (RVGE) using Poisson regression models fit to pooled individual-level data from Phase II and III monovalent rotavirus vaccine trials conducted between 2000 and 2012.
View Article and Find Full Text PDFPolicy effects of reduced pension contribution rate on innovation input--Empirical evidence from Zhejiang and Shandong provinces.
PLoS One
December 2024
School of Internet Economics and Business, Fujian University of Technology, Fuzhou, China.
Reducing pension insurance rates is an important measure for lowering the burden on enterprises. Does this measure encourage enterprises to invest in innovation? This study uses provincial panel data of China during 2000-2017 to analyze the reduction in the proportion of enterprise contributions to pension insurance in Zhejiang and Shandong provinces as a quasi-natural experiment. Specifically, it uses the synthetic control method to construct a counterfactual state of the treatment group, and analyzes the effect of fee reduction policy on enterprise innovation input.
View Article and Find Full Text PDFVector induced humoral responses after rVSVΔG-ZEBOV-GP immunization identify vaccinated individuals and correlate with Ebola virus glycoprotein antibodies.
J Infect Dis
December 2024
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Background: The robustness and persistence of vaccine antigen-induced antibodies are often used as proxy indicators of vaccine efficacy, but immune responses to vaccine vectors are typically less well-defined. Our study considered the kinetics of immunoglobulin (IgG) responses against the vector (vesicular stomatitis Indiana virus [VSIV]) nucleoprotein (N) and the inserted antigen (Ebola virus [EBOV]) glycoprotein (GP1,2) components of the rVSVΔG-ZEBOV-GP (rVSV-ZEBOV) vaccine and evaluated their use as biomarkers to confirm self-reported vaccination status.
Methods: From the Partnership for Research on Ebola Virus in Liberia (PREVAIL) I clinical trial (NCT02344407), we randomly selected 212 participants who received rVSV-ZEBOV (n=107) or placebo (n=105).
Gender differences in the response to antipsychotics or mood stabilizers in patients with acute mania: An individual patient data meta-analysis of placebo-controlled studies.
J Psychiatr Res
November 2024
Department of Psychiatry, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, the Netherlands.
Evidence suggests a worse clinical course in women compared to men with bipolar disorder. However, little research has explored gender differences in the efficacy of anti-manic medication. We sought to determine whether there are gender differences in efficacy of drug treatment in acute manic episodes of bipolar I disorder, and the influence of dichotomized age as a proxy for menopausal status and baseline severity on gender differences.
View Article and Find Full Text PDFSelf-criticism predicts antidepressant effects of intermittent theta-burst stimulation in Major Depressive Disorder.
J Affect Disord
December 2024
Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Mathison Centre for Mental Health Research and Education, Calgary, Alberta, Canada. Electronic address:
Article Synopsis
- Self-criticism may increase the effectiveness of rTMS treatment for depression, with higher levels associated with better outcomes when paired with D-Cycloserine, a drug that enhances synaptic plasticity.
- In a trial with 50 adults diagnosed with Major Depressive Disorder, participants received either D-Cycloserine or a placebo alongside daily rTMS sessions targeting the left dorsolateral prefrontal cortex for 4 weeks.
- Results showed a stronger link between self-criticism and treatment improvement when D-Cycloserine was used, indicating that self-criticism could influence the brain circuits involved in depression response to rTMS.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!