AI Article Synopsis
- Follicular lymphoma is a common B-cell lymphoma made up of follicle center B lymphocytes, with distinct characteristics in pediatric cases and certain extranodal sites compared to adult forms.
- These lymphomas can present as "in-situ," featuring neoplastic cells within normal lymphoid tissue, making them hard to identify in standard tissue sections.
- Recognizing the different morphologic variants and subtypes of follicular lymphoma is crucial to differentiate them from other lymphomas and to identify those with slower, less aggressive clinical behaviors.
Article Abstract
Follicular lymphoma is a relatively common B-cell lymphoma composed of follicle center B lymphocytes. Follicular lymphomas occurring in the pediatric population and in some extranodal sites exhibit particular clinicopathologic features and clinical behavior that are often distinct from adult nodal follicular lymphoma. A type of "in-situ" follicular lymphoma presents as intrafollicular neoplastic cells in a background of architecturally normal lymphoid tissue and may be difficult to recognize in routine sections. Accurate recognition of the morphologic variants and clinicopathologic subtypes of follicular lymphoma is important to avoid confusing them with other lymphomas and reactive processes; in addition, some of these subtypes of follicular lymphoma display unusually indolent clinical behavior that warrant their separation from "conventional" follicular lymphoma.
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| http://dx.doi.org/10.1016/j.path.2010.08.002 | DOI Listing |
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