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Management of Nasopharyngeal Necrosis After Endoscopic Transnasal Resection and Postoperative Radiotherapy in a Patient with Adenoid Cystic Carcinoma.
Ear Nose Throat J
March 2025
Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Microbiota and metabolomic profiling coupled with machine learning to identify biomarkers and drug targets in nasopharyngeal carcinoma.
Front Pharmacol
February 2025
Department of Anesthesiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Background: Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in certain regions, with radiotherapy as the standard treatment. However, resistance to radiotherapy remains a critical challenge, necessitating the identification of novel biomarkers and therapeutic targets. The tumor-associated microbiota and metabolites have emerged as potential modulators of radiotherapy outcomes.
View Article and Find Full Text PDFRadiotherapy Increases Carotid Intima-Media Thickness in Patients with Nasopharyngeal Carcinoma Compared to a Healthy Control Group: A 6-Year Follow-Up Study.
Diagnostics (Basel)
February 2025
Departments of Neurology, Chang Gung Memorial Hospital, Kaohsiung Branch, Kaohsiung City 833, Taiwan.
Vascular abnormalities are the primary histological changes in individuals undergoing radiotherapy for nasopharyngeal carcinoma (NPC). We sought to validate the hypothesis that the duration post-radiotherapy is linked to the progression of carotid intima-media thickness (IMT) and further explored its connection with mortality. Twenty-nine NPC patients who underwent radiotherapy and seventeen healthy controls were examined by carotid ultrasound for measurement of IMT and carotid plaque score at the common carotid artery (CCA), carotid bifurcation, and internal carotid artery, with follow-ups more than 6 years.
View Article and Find Full Text PDFChange in diffusion weighted imaging after induction chemotherapy outperforms RECIST guideline for long-term outcome prediction in advanced nasopharyngeal carcinoma.
Cancer Imaging
March 2025
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong S.A.R, P.R. China.
Purpose: To investigate change in diffusion weighted imaging (DWI) between pre-treatment (pre-) and after induction chemotherapy (post-IC) for long-term outcome prediction in advanced nasopharyngeal carcinoma (adNPC).
Materials And Methods: Mean apparent diffusion coefficients (ADCs) of two DWIs (ADC and ADC) and changes in ADC between two scans (ΔADC%) were calculated from 64 eligible patients with adNPC and correlated with disease free survival (DFS), locoregional recurrence free survival (LRRFS), distant metastases free survival (DMFS), and overall survival (OS) using Cox regression analysis. C-indexes of the independent parameters for outcome were compared with that of RECIST response groups.
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