Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols.

Arch Biochem Biophys

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University of Duesseldorf, D-40225 Dusseldorf, Germany. Electronic address:

Published: June 2016

AI Article Synopsis

  • Cranberries contain various (poly)phenols like proanthocyanidins and anthocyanins, but their absorption and metabolism in humans weren't well understood.
  • In a study, researchers tracked the absorption, metabolism, and excretion of cranberry (poly)phenols in healthy young men after they consumed cranberry juice, identifying 60 unique metabolites.
  • The study found that small phenolic compounds were the most abundant in plasma, with different metabolites appearing at various times post-consumption, and overall only 6.2% of the consumed (poly)phenols were excreted in urine within 24 hours.

Article Abstract

Cranberries are a rich source of (poly)phenols, in particular proanthocyanidins, anthocyanins, flavonols, and phenolic acids. However, little is known about their bioavailability in humans. We investigated the absorption, metabolism, and excretion of cranberry (poly)phenols in plasma and urine of healthy young men after consumption of a cranberry juice (787 mg (poly)phenols). A total of 60 cranberry-derived phenolic metabolites were identified using UPLC-Q-TOF-MS analysis with authentic standards. These included sulfates of pyrogallol, valerolactone, benzoic acids, phenylacetic acids, glucuronides of flavonols, as well as sulfates and glucuronides of cinnamic acids. The most abundant plasma metabolites were small phenolic compounds, in particular hippuric acid, catechol-O-sulfate, 2,3-dihydroxybenzoic acid, phenylacetic acid, isoferulic acid, 4-methylcatechol-O-sulfate, α-hydroxyhippuric acid, ferulic acid 4-O-sulfate, benzoic acid, 4-hydroxyphenyl acetic acid, dihydrocaffeic acid 3-O-sulfate, and vanillic acid-4-O-sulfate. Some benzoic acids, cinnamic acids, and flavonol metabolites appeared in plasma early, at 1-2 h post-consumption. Others such as phenylacetic acids, benzaldehydes, pyrogallols, catechols, hippuric and dihydrocinnamic acid derivatives appear in plasma later (Tmax 4-22 h). The 24 h urinary recovery with respect to the amount of (poly)phenols consumed was 6.2%. Our extensive description of the bioavailability of cranberry (poly)phenols lays important groundwork necessary to start understanding the fate of these compounds in humans.

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http://dx.doi.org/10.1016/j.abb.2016.01.014DOI Listing

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