AI Article Synopsis

  • A series of new coumarin compounds were created to test their ability to kill pancreatic cancer cells under low-nutrient conditions, known as 'antiausterity' activity.
  • Out of 17 compounds, six showed slight effectiveness against PANC-1 pancreatic cancer cells, with Compound 34 demonstrating activity against multiple cancer cell lines (PANC-1, MIA PaCa-2, and Capan-1).
  • These compounds are simpler versions of previously studied natural products, and while some, including Compound 34, have new functionalized triazole structures, their overall effectiveness was lower than that of the natural products they are based on.

Article Abstract

A series of functionalized coumarins were synthesized and evaluated for their capacity to inhibit the resistance to starvation of pancreatic cancer cells. This form of cytotoxicity, termed 'antiausterity' activity, was evaluated using a preferential cytotoxicity assay that compared cell survival in nutrient poor and nutrient rich conditions. Six of the seventeen compounds showed weak antiausterity activity against PANC-1. Compound 34 was active against PANC-1, MIA PaCa-2, and Capan-1 cancer cell lines. All of the compounds tested were simplified structural analogs of previously reported natural product leads. Six of the compounds, including 34, contain functionalized triazoles as novel potential bioisosteres of the side chain of the natural product angelmarin. Overall, the analogs were found to have low antiausterity activity relative to the corresponding natural products.

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http://dx.doi.org/10.1016/j.bmcl.2016.01.054DOI Listing

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  • * Researchers are exploring an "antiausterity strategy," which targets cancer cells under nutrient deprivation, as a potential new approach to treating pancreatic cancer.
  • * In this study, a derivative called Nic-15 showed strong effectiveness against pancreatic cancer cell lines, inhibited tumor growth, and enhanced the effects of gemcitabine in an animal model, suggesting it could be a promising treatment option.
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